Niruj Agrawal

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BACKGROUND One factor contributing to impaired awareness of illness (poor insight) in psychotic disorders may be neurocognitive deficits. METHOD A systematic review and meta-analysis were conducted after data extraction. Following an overall analysis, in which measures of different cognitive domains were taken together, more fine-grained analyses(More)
BACKGROUND About 30% of people with depression do not respond to an antidepressant at the recommended dose and can be described as having treatment-refractory depression. AIMS To summarise the findings from all randomised controlled trials (RCTs) that have assessed the efficacy of a pharmacological or psychological intervention for treatment-refractory(More)
OBJECTIVE These cases illustrate that a new neuroleptic, aripiprazole, may be an effective treatment for the motor and vocal tics of Tourette Syndrome (TS), even in younger people. METHOD A case series of 11 consecutive patients with TS (age range 7-50 years; M = 7) who were felt to require neuroleptic medication, were treated with aripiprazole, the(More)
BACKGROUND Despite the long history of psychogenic nonepileptic seizures (PNES), relatively little is known about the mechanisms that cause and maintain this condition. Emerging research evidence suggests that patients with PNES might have difficulties in regulating their emotions. However, much remains to be learned about the nature of these difficulties(More)
The consequences of epilepsy are often as serious as having the disorder itself. One particularly important consequence is the impairment of cognitive function. The prevalence of memory disorders in people with epilepsy is between 20 and 50%, and over half of these individuals report memory difficulties in daily life. Some patients find these cognitive(More)
BACKGROUND/OBJECTIVE Individuals with spinal cord injury (SCI) have been reported to have an increased prevalence of premature cardiovascular disease. Whether the increased risk of disease is owing to clustering of traditional cardiac risk factor or is over and above that predicted by risk factors was addressed. METHODS Ninety-one persons with chronic SCI(More)
UNLABELLED Ecstasy users have reported that dry mouth, jaw tension and tooth grinding were common side effects of its use although the influence of these effects upon toothwear have not been previously investigated. OBJECTIVE This study aimed to compare incisal and occlusal toothwear in Ecstasy users and a group of non-users of Ecstasy but users of other(More)
PURPOSE The purpose of this study was to identify clinical correlates of self-reported aggressiveness (SRA) in patients with epilepsy treated with levetiracetam (LEV) with special reference to the role of depression. METHODS A consecutive sample of adult outpatients with epilepsy was assessed with the Neurological Disorder Depression Inventory for(More)
PRIMARY OBJECTIVE There has been increasing interest in the role of cholinomimetic agents in the long-term management of cognitive impairment following traumatic brain injury. This paper aims to assess the evidence accumulated thus far. METHODS Studies are identified by searching MEDLINE, EMBASE and PsychINFO, contacting experts and pharmaceutical(More)
OBJECTIVE There is a lack of clarity about the most useful intervention for functional non-epileptic attacks (FNEA). Outcomes for this condition remain often poor, with considerable personal, social and economic impact. In order to guide clinical practice and future research in this area, we have performed a systematic review of the published literature on(More)