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Testicular biopsy, serum and semen samples from bilaterally vasectomized and sham-operated langur monkeys were studied following 1.5, 2.0 and 2.5 years of surgery to assess testis and accessory sex organ function. Testicular degeneration was evident in certain tubules. Circulating levels of serum testosterone were statistically unchanged. Seminal plasma(More)
A long-term vasectomy operation in rat and mouse did not reveal any consistent change in the weights of testis and androgen dependent organs. Histological structure of the testis and caput epididymis remains normal after vasectomy. The androgenic activity of the testis remains normal as reflected by fructose content of seminal vesicles. Pituitary cytology(More)
Administration of single sub-lethal dose (12 mg/kg body wt.) of cadmium chloride neutralizes endogenous hormonal activity in th male Indian Hanuman langur (Presbytis entellus entellus), resulting in a marked decrease in the production of androgens and subsequent reduction in the weights of sex accessory glands. Cadmium chloride in low dose (4 mg/kg body(More)
The contraceptive efficacy and toxicological screening of the two principal compounds, MCP I and ECP I, isolated from the seeds of Carica papaya, in male albino rats at the standardized dose regimen, at 50 mg/kg b.w./day, for a period of 360 days and up to 90 days of treatment withdrawal have been reported. The body and organ weights, cauda epididymal sperm(More)
A combination of danazol (15 mg/kg b.w./day; oral) plus TE (5 mg/kg b.w./15 days; i.m.) was investigated for reversible inhibition of testicular function in rabbit. Testicular histology and biochemistry were studied before, during (30, 60 & 75 days) treatment and 120 days of recovery. A conspicuous decrease in testicular weight and volume with slight(More)
OBJECTIVE A variety of cancers ectopically express human chorionic gonadotropin beta (hCGbeta). Patients harboring such cancers have poor prognosis and adverse survival. A recombinant chimeric antibody, cPiPP, exhibiting high affinity and specificity for hCGbeta/hCG was engineered. This study was designed to determine whether this antibody alone or(More)
It is well established that there is a heritable element of susceptibility to chronic human ailments, yet there is compelling evidence that some components of such heritability are transmitted through non-genetic factors. Due to the complexity of reproductive processes, identifying the inheritance patterns of these factors is not easy. But little doubt(More)
The use of neem (Azadirachta indica) seed extracts (Praneem) given orally for abrogation of pregnancy in subhuman primates is described. Oral administration of Praneem was initiated after confirmation of pregnancy using Leydig cell bioassay estimating rising levels of chorionic gonadotropin (CG) in the blood from day 25 onwards of the cycle and continued(More)
The importance of drugs of plant origin in the pursuit of fertility regulating agents for the male from natural products has long been recognized. This review includes 80 plants with 205 references, up to year 2002. The type of extract, dose, animal model and pharmacological activity of these materials have been reviewed in this paper to add impetus to(More)