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Voltage-gated sodium channels (VGSCs) are a family of transmembrane proteins that mediate fast neurotransmission, and are integral to sustain physiological conditions and higher cognitive functions. Imaging of VGSCs in vivo holds promise as a tool to elucidate operational functions in the brain and to aid the treatment of a wide range of neurological(More)
In vivo imaging of voltage-gated sodium channels (VGSCs) can potentially provide insights into the activation of neuronal pathways and aid the diagnosis of a number of neurological diseases. The iminodihydroquinoline WIN17317-3 is one of the most potent sodium channel blockers reported to date and binds with high affinity to VGSCs throughout the rat brain.(More)
— Chip multithreaded computing is exposed to the dual challenges of increasing system complexity and error sensitivity. It is critical to develop effective solutions that achieve better error tolerance without inducing performance degradation. In this paper, we propose a new error-tolerant memory design based on a unique computing phenomenon referred to as(More)
— Presented in this paper is a joint algorithm optimization and architecture design framework for analysis of repetitive regularities. Two closely coupled algorithm optimization techniques, referred to as the prime sub-space periodicity transform (PSPT) and circular periodicity transform (CPT), are developed that significantly reduce computational(More)
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