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MicroRNAs (miRNAs) are ∼22-nt long, non-coding RNAs that regulate gene silencing. It is known that many human miRNAs are deregulated in numerous types of tumors. Here we report the sequencing of small RNAs (17-25 nt) from 23 breast, bladder, colon and lung tumor samples using high throughput sequencing. We identified 49 novel miRNA and miR-sized small RNAs.(More)
Previously, it was shown that predicting selective mutations leading to topological transitions in the secondary structure of RNAs can be achieved by a coarse-grain Laplacian matrix tree graph representation using its second eigenvalue. When applying the coarse-grain tree graph representation, introduced by Shapiro and coworkers in the 80's, it is possible(More)
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