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2 6 2 7 Mycobacterium tuberculosis (Mtb) lineage identification and typing of clinical isolates in 2 8 general is performed only retrospectively. The results are rarely linked to drug susceptibility 2 9 testing (DST) or patient data. Consequently, the association between Mtb lineage, 3 0 (multi)drug resistance and treatment history is not fully explored at(More)
The aminoglycosides kanamycin and amikacin and the macrocyclic peptide capreomycin are key drugs for the treatment of multidrug-resistant tuberculosis (MDR-TB). The increasing rates of resistance to these drugs and the possible cross-resistance between them are concerns for MDR-TB therapy. Mutations in the 16S rRNA gene (rrs) have been associated with(More)
Multiplex ligation-dependent probe amplification (MLPA) is a powerful tool to identify genomic polymorphisms. We have previously developed a single nucleotide polymorphism (SNP) and large sequence polymorphisms (LSP)-based MLPA assay using a read out on a liquid bead array to screen for 47 genetic markers in the Mycobacterium tuberculosis genome. In our(More)
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