Nino Bzekalava

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2 6 2 7 Mycobacterium tuberculosis (Mtb) lineage identification and typing of clinical isolates in 2 8 general is performed only retrospectively. The results are rarely linked to drug susceptibility 2 9 testing (DST) or patient data. Consequently, the association between Mtb lineage, 3 0 (multi)drug resistance and treatment history is not fully explored at(More)
Multiplex ligation-dependent probe amplification (MLPA) is a powerful tool to identify genomic polymorphisms. We have previously developed a single nucleotide polymorphism (SNP) and large sequence polymorphisms (LSP)-based MLPA assay using a read out on a liquid bead array to screen for 47 genetic markers in the Mycobacterium tuberculosis genome. In our(More)
The aminoglycosides kanamycin and amikacin and the macrocyclic peptide capreomycin are key drugs for the treatment of multidrug-resistant tuberculosis (MDR-TB). The increasing rates of resistance to these drugs and the possible cross-resistance between them are concerns for MDR-TB therapy. Mutations in the 16S rRNA gene (rrs) have been associated with(More)
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