Ningning Chen

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Recent studies indicate that progesterone (PROG) protects against animal brain injury, including ischemic stroke, in various animal models. However, there are insufficient studies about PROG in other various groups such as ovariectomized females and aged animals. This study was designed to examine the efficacy of PROG on infarct volume, brain water content(More)
BACKGROUND Hypertension is a major, modifiable risk factor for cardiovascular and kidney disease and premature mortality that is improved by the DASH (Dietary Approaches to Stop Hypertension) diet. The DASH diet emphasizes increased consumption of fruit and vegetables, whole grains, low-fat dairy, nuts, and poultry and fish and reduced intakes of fats, red(More)
We evaluated the inhibitory effects of progesterone (PROG) on inflammatory response and its influence on the structure of blood–brain barrier in a permanent model of stroke. One hundred and twenty adult male Sprague-Dawley rats were used in this study. PROG was dissolved in 22.5% 2-hydroxypropyl-bcyclodextrin and given in a dose of 15 mg/kg by(More)
Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known. Fifteen overweight adults (5 female, 10 male; BMI: 27.1 ± 0.2 kg/m²; aged 26 ± 1 year) consumed four breakfast meals in a randomized crossover manner (normal(More)
OBJECTIVE The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. METHODS A priori brain regions of(More)
BACKGROUND Limited and inconsistent research findings exist about the effect of dietary protein intake on indexes of sleep. OBJECTIVE We assessed the effect of protein intake during dietary energy restriction on indexes of sleep in overweight and obese adults in 2 randomized, controlled feeding studies. DESIGN For study 1, 14 participants [3 men and 11(More)
Nuts have high energy and fat contents, but nut intake does not promote weight gain or obesity, which may be partially explained by their proposed high satiety value. The primary aim of this study was to assess the effects of consuming almonds versus a baked food on postprandial appetite and neural responses to visual food stimuli. Twenty-two adults (19(More)
Dietary protein and fiber independently influence insulin-mediated glucose control. However, potential additive effects are not well-known. Men and women (n = 20; age: 26 ± 5 years; body mass index: 26.1 ± 0.2 kg/m²; mean ± standard deviation) consumed normal protein and fiber (NPNF; NP = 12.5 g, NF = 2 g), normal protein and high fiber (NPHF; NP = 12.5 g,(More)
BACKGROUND Postoperative pain and opioid use are associated with postoperative delirium. We designed a single-center, randomized, placebo-controlled, parallel-arm, double-blinded trial to determine whether perioperative administration of gabapentin reduced postoperative delirium after noncardiac surgery. METHODS Patients were randomly assigned to receive(More)
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