Ningkun Zhang

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Substantial reorganization of mossy fibers from granule cells of the dentate gyrus occurs in a high percentage of humans with medically intractable temporal lobe epilepsy. To identify these fibers and determine their ultrastructural features in human surgical specimens, we used preembedding immunoperoxidase labeling of dynorphin A, an opioid peptide that is(More)
The physiological link between neuropathic pain and depression remains unknown despite a high comorbidity between these two disorders. A mouse model of spared nerve injury (SNI) was used to test the hypothesis that nerve injury precipitates depression through the induction of inflammation in the brain, and that prior exposure to stress exacerbates the(More)
The neuropeptide cholecystokinin (CCK) is abundant in the CNS and is expressed in a subset of inhibitory interneurons, particularly in their axon terminals. The expression profile of CCK undergoes numerous changes in several models of temporal lobe epilepsy. Previous studies in the pilocarpine model of epilepsy have shown that CCK immunohistochemical(More)
Stem cells derived from umbilical cord Wharton's jelly (WJSCs) are not immunogenic and have immunosuppressive effects. To evaluate the related mechanisms and the effect of transplantation on body immune cells, we examined immune property genes expression in WJSCs and levels of T-lymphocytes subgroups and immunoglobulins (Ig) in heart failure (HF) patients(More)
Radiation-induced lung injury (RILI) limits the benefits of radiotherapy in patients with lung cancer. Radiation-induced differentiation of lung fibroblasts to myofibroblasts plays a key role in RILI. Recent studies have shown that mesenchymal stem cells (MSCs) can protect against lung fibrosis and that Wnt/β-catenin signaling is involved in fibrotic(More)
209 Received October 24, 2014; revised and accepted June 2, 2015. Published online June 24, 2015; doi: 10.1620/tjem.236.209. *These two authors contributed equally to this study. Correspondence: Huasong Feng, Respiratory Department, Navy General Hospital, No.6 Fucheng Road, Haidian District, Beijing 100048, P.R. China. e-mail:
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