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Cell competition is a homeostatic mechanism that regulates the size attained by growing tissues. We performed an unbiased genetic screen for mutations that permit the survival of cells being competed due to haplo-insufficiency for RpL36. Mutations that protect RpL36 heterozygous clones include the tumor suppressors expanded, hippo, salvador, mats, and(More)
RESEARCH OBJECTIVE To develop scalable informatics infrastructure for normalization of both structured and unstructured electronic health record (EHR) data into a unified, concept-based model for high-throughput phenotype extraction. MATERIALS AND METHODS Software tools and applications were developed to extract information from EHRs. Representative and(More)
It is well recognized that controlled medical terminologies play a critical role in Health Information Systems and Clinical Patient Record systems, but the creation and management of customized lists of terms ("picklists") remains a potential obstacle. We have been developing a sophisticated authoring tool that is fully integrated with our terminology(More)
Traditional packet classification algorithms in Giga bit Intrusion Detection System (GIDS) always focus on static characteristic of the signature and ignore the traffic characteristic totally. In this paper we argue that efficiency of the classification algorithm is up to how current traffic visits the tree, the more well-proportioned the classification(More)
OBJECTIVE The objective of the Strategic Health IT Advanced Research Project area four (SHARPn) was to develop open-source tools that could be used for the normalization of electronic health record (EHR) data for secondary use--specifically, for high throughput phenotyping. We describe the role of Intermountain Healthcare's Clinical Element Models ([CEMs](More)
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