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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
TLDR
It is demonstrated that Aβ-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Aβ to mitochondrial toxicity and the ABAD-Aβ interaction may be a therapeutic target in Alzheimer's disease. Expand
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
TLDR
These results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs, and highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots. Expand
Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia
TLDR
Using whole-exome sequencing followed by Sanger sequencing, three truncating mutations within PRRT2 were identified in eight Han Chinese families with histories of paroxysmal kinesigenic dyskinesia and co-segregated exactly with the disease in these families and were not observed in 1,000 control subjects of matched ancestry. Expand
Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
TLDR
Through extensive coalescent simulations and analysis of published haplotype data on chromosome 21, it is found that the combined effects of population demographic history, recombination, and mutation dictate haplotype block characteristics and haplotype blocks can arise in the absence of recombination hot spots. Expand
Agrobacterium-mediated sorghum transformation
TLDR
The first report of successful use of Agrobacterium for production of stably transformed sorghum plants is reported, with the method yields a higher frequency of stable transformation that other methods reported previously. Expand
Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana.
TLDR
It is concluded that the four Ib subgroup bHLH proteins are required and possess redundant functions with differential significance for activation of iron-deficiency responses and uptake in Arabidopsis. Expand
Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction.
TLDR
Increased circulating miR-1 level was significantly higher in plasma from AMI patients compared with non-AMI subjects and the level was dropped to normal on discharge following medication, revealing that circulating miD-1 may be a novel, independent biomarker for diagnosis of AMI. Expand
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
TLDR
It is demonstrated that intracellular Aβ is present in mitochondria from brains of transgenic mice with targeted neuronal overexpression of mutant human amyloid precursor protein and AD patients, delineating a new means through which Aβ potentially impairs neuronal energetics, contributing to cellular dysfunction in AD. Expand
Influence of cooking and dehulling on nutritional composition of several varieties of lentils (Lens culinaris)
The effect of cooking and dehulling on nutrients and anti-nutritional factors of several varieties of lentils (Lens culinaris) was investigated. Significant (p < 0.05) variations existed among theExpand
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
TLDR
It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases. Expand
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