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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase (ABAD) is a direct… Expand
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
The 2002–3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East… Expand
Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia
Paroxysmal kinesigenic dyskinesia is the most common type of paroxysmal movement disorder and is often misdiagnosed clinically as epilepsy. Using whole-exome sequencing followed by Sanger sequencing,… Expand
Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation.
- Ning Wang, J. Akey, K. Zhang, R. Chakraborty, L. Jin
- Biology, Medicine
- American journal of human genetics
- 1 November 2002
Recent studies suggest that haplotypes are arranged into discrete blocklike structures throughout the human genome. Here, we present an alternative haplotype block definition that assumes no… Expand
Agrobacterium-mediated sorghum transformation
Agrobacterium tumefaciens was used to genetically transform sorghum. Immature embryos of a public (P898012) and a commercial line (PHI391) of sorghum were used as the target explants. The… Expand
Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana.
The Ib subgroup of the bHLH gene family in Arabidopsis contains four members (AtbHLH38, AtbHLH39, AtbHLH100, and AtbHLH101). AtbHLH38 and AtbHLH39 were previously confirmed to interact with FER-like… Expand
Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction.
Recent studies have revealed the role of microRNAs (miRNAs) in a variety of basic biological and pathological processes and the association of miRNA signatures with human diseases. Circulating miRNAs… Expand
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Although amyloid‐β peptide (Aβ) is the neurotoxic species implicated in the pathogenesis of Alzheimer's disease (AD), mechanisms through which intracellular Aβ impairs cellular properties, resulting… Expand
Influence of cooking and dehulling on nutritional composition of several varieties of lentils (Lens culinaris)
The effect of cooking and dehulling on nutrients and anti-nutritional factors of several varieties of lentils (Lens culinaris) was investigated. Significant (p < 0.05) variations existed among the… Expand
Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions
- F. Chowdhury, Y. Li, Yeh-Chuin Poh, Tamaki Yokohama-Tamaki, Ning Wang, T. Tanaka
- Medicine, Biology
- PloS one
- 13 December 2010
Maintaining undifferentiated mouse embryonic stem cell (mESC) culture has been a major challenge as mESCs cultured in Leukemia Inhibitory Factor (LIF) conditions exhibit spontaneous differentiation,… Expand