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BACKGROUND The distribution of HLA alleles and haplotypes varies widely between different ethnic populations and geographic areas. Before any genetic marker can be used in a disease-associated study it is therefore essential to investigate allelic frequencies and establish a genetic database. METHODOLOGY/PRINCIPAL FINDINGS This is the first report of HLA(More)
AIM The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. METHODS Blood samples were collected from both groups,(More)
T. Ji, Dr. Y. Ding, Dr. Y. Zhao, J. Wang, H. Qin, J. Lang, R. Zhao, Y. Zhang, J. Shi, Prof. G. Nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) 11 Beiyitiao, Zhongguancun Beijing 100190 , China E-mail: zhaoying@nanoctr.cn; niegj@nanoctr.cn X. Liu, Dr. N. Tao, Prof. Z. Qin(More)
A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive to fibroblast activation protein-α (FAP-α), a protease specifically expressed on the surface of cancer-associated fibroblasts. The CAP self-assembled into fiber-like nanostructures in solution, while the presence of hydrophobic chemotherapeutic drugs readily transformed(More)
Reversing the function of immune suppressor cells may improve the efficacy of cancer therapy. Here, we have isolated a novel polysaccharide MPSSS (577.2 Kd) from Lentinus edodes and examined its effects on differentiation and function of myeloid-derived suppressor cells (MDSCs). MPSSS is composed of glucose (75.0%), galactose (11.7%), mannose (7.8%), and(More)
A method of sequence-based typing (SBT) has been adopted to assort types of exons 2 and 3, which have the most polymorphism, of HLA-B locus of the Tujia nation group in Hubei province. The correlation among the HLA-B alleles, human papillomavirus (HPV) infection and cervical cancer risk has also been investigated. Under the condition of resident location(More)
The aim of this survey was to assess the prevalence and type distribution of oncogenic human papillomavirus (HPV) infections among women in Wufeng County of Hubei province, where the cervical cancer mortality rate is the highest in China Cervical. DNA samples were collected from 1,100 women, then screened and quantified by a multi-fluorescent, quantitative(More)
We have developed a novel micro-mixer using a biological molecular ATP motor. The micro-mixer was constructed from arrays of chromatophore-embedded delta-free F(0)F(1)-ATPases, where the delta-free F(1) part acted as a rotator to mix solutions, and the F(0) part was driven by light. Confocal microscope studies indicated that the micro-mixer did not touch(More)
Mounting evidence has demonstrated that CD4+ T cells play an important role in anti-tumor immune responses. Thus, adoptive transfer of these cells may have great potential for anti-cancer therapy. However, due to the difficulty to generate sufficient tumor-specific CD4+ T cells, the use of CD4+ T cells in tumor therapy is limited. It has been found that(More)