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This paper introduces a new design approach that combines logic and layout synthesis for Cellular-Architecture (CA) FPGAs. The comprehensive design method starts from a Boolean function, specified as SOP or ESOP, and produces a rectangularly-shaped multi-level structure of (mostly) locally connected cells. This two-dimensional array of logic cells is well(More)
Growing evidence suggests that iron accumulation in the substantia nigra (SN) is involved in the pathology of Parkinson's diseases (PD). Divalent metal transporter 1 (DMT1) is an endogenous transporter for ferrous iron, the levels of which are significantly increased in the SN in postmortem PD brains. To study the possible association of DMT1 gene with PD(More)
This paper presents a new operation (Exorlink) and an algorithm to minimize Exclusive-OR Sum-of-Products expressions (ESOPs) for multiple valued input, two valued output, incompletely speciied functions. Exorlink is a more powerful operation than the existing ones for this problem. Evaluation on benchmark functions is given and it proves the superiority of(More)
Intracellular Lewy body formation is one of the hallmarks of Parkinson's disease (PD). As its main component, aggregated α-synuclein is presented in the substantia nigra, the same region iron accumulation occurs. In this study, the relationship between iron and α-synuclein aggregation was investigated. In the remaining cells, 1 mmol/l ferric and ferrous(More)
Increased nigral iron levels and intracytoplasmic Lewy bodies (LBs) in the degenerating neurons are found in Parkinson's disease (PD). Whether LBs formation is involved in the toxicity of iron is largely unknown. In the present study, we observed that the toxicity of ferric iron was enhanced when SK-N-SH cells were overexpressed with wild-type(More)
A new cube operation, exorlink, is presented, as well as its application to the minimization of multiple-valued input, multi-output Exclusive Sums Of Products (ESOPs) for incompletely specified Boolean functions. Exorlink generalizes all cube operations such as crosslink. unlink or X-merge introduced by Helliwell, Perkowski, Sasao and other authors. Our(More)
Cumulative studies indicated that adult hippocampal neurogenesis might be involved in the action mechanism of antidepressant drugs and/or the pathophysiology of depression. Dopamine (DA) is involved in the regulation of motivation, volition, interest/pleasure, and attention/concentration, all of which are likely to be impaired in depressed patients. Several(More)
We derive necessary and sufficient conditions which guarantee that a multiplying set of monomials generates exactly a Sylvester A-resultant for three bivariate polynomials with a given planar Newton polygon. We show that valid multiplying sets come in complementary pairs, and any two complementary pairs of multiplying sets can be used to index the rows and(More)
Histone modification has been implicated in the regulation of mammalian spermatogenesis. However, the association of differently modified histone H3 with a specific stage of germ cells during spermatogenesis is not fully understood. In this study, we examined the localization of variously modified histone H3 in paraffin-embedded sections of adult mouse(More)