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BACKGROUND Sequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long queries or database sequences. There are also some shortcomings in the user-interface of the current(More)
Recent studies suggest that a brain network mainly associated with episodic memory has a more general function in imagining oneself in another time, place or perspective (e.g. episodic future thought, theory of mind, default mode). If this is true, counterfactual thinking (e.g. 'If I had left the office earlier, I wouldn't have missed my train.') should(More)
This study explores the fMRI correlates of observers making trait inferences about other people under conflicting social cues. Participants were presented with several behavioral descriptions involving an agent that implied a particular trait. The last behavior was either consistent or inconsistent with the previously implied trait. This was done under(More)
It is widely accepted that addictive drug use is related to abnormal functional organization in the user's brain. The present study aimed to identify this type of abnormality within the brain networks implicated in addiction by resting-state functional connectivity measured with functional magnetic resonance imaging (fMRI). With fMRI data acquired during(More)
The Basic Local Alignment Search Tool (BLAST) website at the National Center for Biotechnology (NCBI) is an important resource for searching and aligning sequences. A new BLAST report allows faster loading of alignments, adds navigation aids, allows easy downloading of subject sequences and reports and has improved usability. Here, we describe these(More)
Distant microphone speech recognition systems that operate with human-like robustness remain a distant goal. The key difficulty is that operating in everyday listening conditions entails processing a speech signal that is rever-berantly mixed into a noise background composed of multiple competing sound sources. This paper describes a recent speech(More)
We present a new corpus designed for noise-robust speech processing research, CHiME. Our goal was to produce material which is both natural (derived from reverberant domestic environments with many simultaneous and unpredictable sound sources) and controlled (providing an enumerated range of SNRs spanning 20 dB). The corpus includes around 40 hours of(More)
This fMRI study analyzes inferences on other persons' traits, whereby half of the participants were given spontaneous ("read") instructions while the other half were given intentional ("infer the person's trait") instructions. Several sentences described the behavior of a target person from which a strong trait could be inferred (trait diagnostic) or not(More)
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel (KCNQ1/KCNE1), the(More)