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OBJECTIVE To summarize the prevalence of retinal vein occlusion (RVO) from studies in the United States, Europe, Asia, and Australia. DESIGN Pooled analysis using individual population-based data. PARTICIPANTS Individual participant data from population-based studies around the world that had ascertained RVO from fundus photographs. METHODS Each study(More)
PURPOSE To describe the prevalence and risk factors of diabetic retinopathy in Asian Malays. DESIGN Population-based cross-sectional study. PARTICIPANTS Persons with diabetes of Malay ethnicity aged 40 to 80 years in Singapore. METHODS Diabetes mellitus was defined as random glucose of 11.1 mmol/l or more, use of diabetic medication, or a physician(More)
OBJECTIVE To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature. CLINICAL RELEVANCE Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are(More)
OBJECTIVE To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature. CLINICAL RELEVANCE Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear. METHODS Systemic(More)
OBJECTIVE Fractals represent a type of derived geometric pattern that permits the characterization of the branching pattern of retinal vessels. We examined a new semiautomated method to measure retinal vessel fractals. DESIGN Methodology study. PARTICIPANTS Three hundred randomly selected participants from the population-based Blue Mountains Eye Study.(More)
PURPOSE To report the outcome of oral chlorambucil as a single treatment in patients with orbital mucosa-associated lymphoid tissue (MALT) lymphoma. DESIGN Retrospective nonrandomized clinical study. PARTICIPANTS Thirty-three patients with isolated orbital MALT lymphoma. METHODS Medical records of all patients with histology-verified orbital MALT(More)
There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber.(More)
Retinopathy is the most common complication of diabetes. The assessment of retinopathy signs presents clinicians a unique opportunity to directly visualize and assess the actual morphology of diabetic microvascular damage. Extensive studies have now shown that people with diabetic retinopathy have excess risks of systemic vascular complications, including(More)
The prevalence of obesity has reached epidemic proportions in many countries. Although its impact on overall health is well documented, less is known about the ocular manifestations of obesity. Among different eye diseases, obesity has been linked with age-related cataract, glaucoma, age-related maculopathy, and diabetic retinopathy. Numerous(More)
Retinal arteriolar narrowing is a known response of hypertension and independently predicts cardiovascular mortality in adults. Whether elevated blood pressure leads to retinal arteriolar narrowing in young children is unknown. We examined the relationship of retinal vascular caliber and blood pressure levels in 2 population-based cohorts among children(More)