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BACKGROUND Since the single nucleotide polymorphisms (SNPs) are genetic variations which determine the difference between any two unrelated individuals, the SNPs can be used to identify the correct source population of an individual. For efficient population identification with the HapMap genotype data, as few informative SNPs as possible are required from(More)
—In this paper, we argue that for a C-class classification problem, C 2-class classifiers, each of which discriminating one class from the other classes and having a characteristic input feature subset, should in general outperform, or at least match the performance of, a C-class classifier with one single input feature subset. For each class, we select a(More)
Single nucleotide polymorphisms (SNPs) are genetic variations that determine the differences between any two unrelated individuals. Various population groups can be distinguished from each other using SNPs. For instance, the HapMap dataset has four population groups with about ten million SNPs. For more insights on human evolution, ethnic variation, and(More)
AbstrAct This chapter introduces an approach to class-dependent feature selection and a novel support vector machine (SVM). The relative background and theory are presented for describing the proposed method, and real applications of the method on several biomedical datasets are demonstrated in the end. The authors hope this chapter can provide readers a(More)
In this paper, we attempt to answer the following question with systematic computer simulations: for the same validation error rate, does the size of a feedforward neural network matter? This is related to the so-called Occam's Razor, that is, with all things being equal, the simplest solution is likely to work the best. Our simulation results indicate that(More)
RAF kinase inhibitor protein (RKIP) is a negative regulator of the RAS-mitogen-activated protein kinase/extracellular signal-regulated kinase signaling cascade. We investigated the expression of RKIP in chronic myelogenous leukemia (CML) K562 cells and the effects of RKIP on the characteristics of K562 cells. The recombinant plasmid pcDNA3.1-RKIP was(More)
OBJECTIVE To investigate the effect of fluorescent dye labeling on the targeting capabilities of 111In- (DTPA)n-trastuzumab-(IRDye 800)m. METHODS Trastuzumab-based conjugates were synthesized and conjugated with diethylenetriaminepentaacetic acid (DTPA) at molar ratios of 1, 2, 3 and 5 and with a fluorescent dye (IRDye 800CW) at molar ratios of 1, 3 and(More)