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—In this paper, we argue that for a C-class classification problem, C 2-class classifiers, each of which discriminating one class from the other classes and having a characteristic input feature subset, should in general outperform, or at least match the performance of, a C-class classifier with one single input feature subset. For each class, we select a(More)
BACKGROUND Since the single nucleotide polymorphisms (SNPs) are genetic variations which determine the difference between any two unrelated individuals, the SNPs can be used to identify the correct source population of an individual. For efficient population identification with the HapMap genotype data, as few informative SNPs as possible are required from(More)
AbstrAct This chapter introduces an approach to class-dependent feature selection and a novel support vector machine (SVM). The relative background and theory are presented for describing the proposed method, and real applications of the method on several biomedical datasets are demonstrated in the end. The authors hope this chapter can provide readers a(More)
In this paper, we attempt to answer the following question with systematic computer simulations: for the same validation error rate, does the size of a feedforward neural network matter? This is related to the so-called Occam's Razor, that is, with all things being equal, the simplest solution is likely to work the best. Our simulation results indicate that(More)
OBJECTIVE To investigate the effect of fluorescent dye labeling on the targeting capabilities of 111In- (DTPA)n-trastuzumab-(IRDye 800)m. METHODS Trastuzumab-based conjugates were synthesized and conjugated with diethylenetriaminepentaacetic acid (DTPA) at molar ratios of 1, 2, 3 and 5 and with a fluorescent dye (IRDye 800CW) at molar ratios of 1, 3 and(More)
The single nucleotide polymorphisms (SNPs) are believed to determine human differences and, to some degree, provide biomedical researchers a possibility of predicting risks of some diseases and explaining patients' different responses to drug regimens. With the availability of millions of SNPs in the Hapmap Project, although large amount of information(More)
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