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The determination of the physical map of human chromosome 11 will require more clones than are currently available. We have isolated an additional 1001 new markers in a bacteriophage vector from a somatic cell hybrid cell line that contains most of chromosome 11, except the middle of the short arm. These markers were localized to five different regions,(More)
Chromosome complements of three species of Callithricidae, Saguinus oedipus, Saguinus fuscicollis and Callithrix jacchus, were analyzed by various banding techniques. Morphometric data are presented. A diploid chromosome number of 2n = 46 is reconfirmed for all three species. Several interesting interspecies chromosomal variations were demonstrated by G-(More)
Karyotypic study of a population sample of twenty-one owl monkeys, Aotus, originating from Bolivia, revealed two sex-specific somatic diploid chromosome numbers: 49 for males and 50 for females. The presence of a trivalent in male meiotic figures and the identification of chromosomes by band pattern analysis confirmed the interpretation of a Y-autosome(More)
Diploid numbers, chromosome morphology, G- and C-banding characterisitics and pelage phenotypes were studied in 330 owl monkeys (Aotus) captured and exported from several parts of South America. Among these animals, seven distinctive karyotypes were recognized by the number of chromosomes and their individual identification by G- and C-banding methods.(More)
The chromosome complement of a group of owl monkeys with typical pelagic features characteristic of Aotus inhabiting the upper Amazonian region in South America was analyzed by various band techniques. A diploid chromosome number of 2n = 52 is reconfirmed in the females. A Y-autosome translocation resulting in a complement of 2n = 51 in the males(More)
Variant structural homozygosity, observed previously only in plants and insects, is reported herein for the first time in mammalian chromosomes. The addition of a heterochromatic chromosome segment to either one or both homologues is described in autosomes B5 and B12 of the squirrel monkey, Saimiri sciureus.
Scurvy was diagnosed in seven children at Boston Children's Hospital. All of the children had a developmental disorder and autism was the most common. They had a long-standing history of food selectivity with diets devoid of fruits and vegetables, and none of the children were supplemented with a multivitamin. They presented with limp, and an elaborate(More)
The critical importance of dosage compensation is underscored by a novel human syndrome ("XYXq syndrome") in which we have detected partial X disomy, demonstrated supernormal gene expression resulting from the absence of X inactivation, and correlated this overexpression with its phenotypic consequences. Studies of three unrelated boys with 46,XYq-(More)
We have combined genetic, radiation-reduced somatic cell hybrid (RRH), fluorescent in situ hybridization (FISH), and physical mapping methods to generate a contig of overlapping YAC, PAC, and cosmid clones corresponding to > 3 continuous Mb in 11q13. A total of 15 STSs [7 genes (GSTP1, ACTN, PC, MLK3, FRA1, SEA, HNP36), 4 polymorphic loci (D11S807, D11S987,(More)
PURPOSE OF REVIEW Gynecomastia is often benign, but it can be the sign of serious endocrine disease and the source of significant embarrassment and psychological stress. Understanding its pathogenesis is crucial to distinguish a normal developmental variant from pathological causes. RECENT FINDINGS There is a growing list of potential causes of(More)