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The process of aging is one of the most complex and intriguing biological phenomenons. Aging is a genetically regulated process in which the organism's maximum lifespan potential is pre-determined, while the rate of aging is influenced by environmental factors and lifestyle. Considering the complexity of mechanisms involved in the regulation of aging(More)
OBJECTIVE The aim of this study was to investigate the association of functional MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB. METHODS AND(More)
A number of case-control studies investigated the association between idiopathic recurrent spontaneous abortion (IRSA) and variations in the gene encoding endothelial nitric oxide synthase (NOS3), but yielded contradictory results. Our aim was to test the association of the NOS3 variable number of tandem repeats (VNTR) in intron 4 and +894 G/T(More)
The aim of this mini-review is to give an overview of the current controversies and advances regarding the definition and causes of recurrent spontaneous abortion, with particular emphasis on genetic factors. The presented knowledge is based on the most recent findings of observational and experimental studies, as well as systematic reviews and(More)
Aim: Ring chromosomes are rare structural chromosomal aberrati ons which form aft er the breakage in both terminal regions of the aff ected chromosome with fusion of the short and long arm into a ring formati on. The incidence of ring chromosome syndromes is esti mated to be about 1:50.000 live born children. Here we present the fi rst case of a girl with(More)
strukturnim anomalijama. Abstract. Determination of diagnosis in children and adults with dysmorphic clinical features , multiple congenital anomalies and/or mental retardation, as well as understanding their etiology and pathogenesis enables the prediction of the course of congenital disorders, direction of clinical analysis, genetic counselling and(More)
(simptomima i znakovima), odnosno njihovim kombinacijama, čime se dobiva ispis najizgled-nijih genetičkih poremećaja, dobiveni popis samo je prvi korak u dijagnostičkom procesu, te zahtijeva daljnje proučavanje medicinski relevantne literature, kao i ponovne preglede djeteta kada se ciljano traže specifična obilježja i dodatna klinička obrada. ABSTRACT.(More)
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