Nina I. Zhernakova

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Chronic glomerulonephritis (CGN) is one of the most severe kidney diseases. Genes of vascular reactivity are thought to play an important role in development and progression of CGN. In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and(More)
A rationale is proposed for the principles and strategy of non-medicamentous therapy of duodenal ulcer (DU) developing in the advanced age and assessment of its socio-medical efficiency. Staged treatment was given to 234 patients in whom DU was diagnosed between 61 and 65 (mean 63.2) years of age. Basic therapy and long-term dynamic follow-up were carried(More)
The problem of duodenal ulcer (DU) in one of the most important issues in gastroenterology. Successful eradication of Helicobacter pylori leads to a significant decrease in the frequency of DU recurrence. However, in spite of modern achievement, this disease cannot be cured completely. Taking into account melatonin properties as well as the results of(More)
Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in(More)
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted(More)
The paper presents data on interaction of candidate genes (S311C PON2, (-6)A/G AGT, (-1166)A/C AGTR1, (-592)C/A IL-10, VNTR IL-1Ra, T113M IL-9, K198N EDN1, (+46)G/A ADRB2, G/A GNB3 (rs.2301339)) with oligogenic and continuous characters of chronic glomerulonephritis. The associations of polymorphisms (-6) A/G AGT and VNTR IL-1Ra with acute nephritic and(More)
Neuroimmunoendocrinology is a new science studying the interplay between major regulatory systems (nervous, endocrine, and immune) mediated through regulatory (signal) molecules. Its applied aspects concern elucidation of the influence of various exogenous factors on the organism manifested as alteration of signal molecule homeostasis. Effects of ethanol on(More)
Clinical symptoms of ulcer disease in aged patients were found to depend on the degree of Helicobacter pylori (Hp) mucosal infection. Epigastralgia more frequently associated with grade III than grade I Hp infection (87.5 and 61.9% respectively, p < 0.05). In contrast, pain of a different localization largely occurred in patients with milder infection(More)
The authors present the results of an open prospective study undertaken to elucidate the influence of combined treatment of 72 patients presenting with chronic obstructive pulmonary disease (COPD). It was shown that traditional therapy supplemented by physical rehabilitation procedures, psychotherapy, and patient education during 6 months resulted in(More)