Nina Elisabeth Staffansdotter Sohlman Perrin

Learn More
We compared renal morphology in normoalbuminuric adolescents with type 1 diabetes with age-and sex-matched controls. Renal morphological measurements in 46 unselected adolescents with diabetes for approx. 10 years were compared with those in 20 healthy kidney donors. Renal volume estimated by ultra-sound, renal function determined by clearances of inulin(More)
Determination of the factors influencing renal vascular resistance (RVR) at very low perfusion pressures (RPP) is of interest, since prolonged periods of reduced perfusion can lead to acute renal failure. We have studied the effects of inhibition of the renin-angiotensin system on renal blood flow (RBF), measured by electromagnetic flow probe, over a(More)
The hemodynamics of the rat kidney were studied during reduction of renal arterial pressure to 35-40 mm Hg (H), and after volume expansion at that pressure with 0.9% NaCl (IS), 1.7% NaCl (HS), 5% mannitol in 0.9% NaCl (MS), 5% mannitol in water (MW), or 50 mM mannitol + 125 mM NaCl. During H, left renal blood flow (RBF) was 0.8+/-0.1 ml/min. Expansion with(More)
We have previously reported that mannitol strikingly increases blood flow to rat kidneys hypoperfused at 35-40mm Hg. This vasodilator effect is not due to volume expansion or alterations in plasma osmolality. We have tested the hypothesis that the vasodilatory effect of mannitol in the ischemic rat kidney is mediated by one of the vasoactive renal hormone(More)
Our objective was to study the effects of candesartan on diabetic glomerulopathy in young normoalbuminuric and normotensive patients with type 1 diabetes in a double-blind, placebo-controlled trial. In 13 patients aged 24 years at baseline, we evaluated blood pressure, kidney biopsies and kidney function tests at baseline and after 5 years of treatment.(More)
To study the development of diabetic glomerulopathy, we performed two kidney biopsies after 10.5 and 17 years of type 1 diabetes in 19 normoalbuminuric, normotensive adolescents (10 males). The biopsies were examined with light and electron microscopy. The glomerular filtration rate and effective renal plasma flow, determined with inulin and(More)
Renal perfusion pressure (RPP), total renal blood flow (RBF), and renal vascular resistance (RVR) were comparable in groups of rats placed on high (HS) or low sodium (LS) diets for several weeks (HS, RVR = 16.4 ± 0.6; LS, RVR = 17.4 ± 0.6 mm Hg/ml per min). However, urinary kallikrein excretion was significantly lower in HS (0.31 ± 0.05U/min) than LS rats(More)
BACKGROUND Nephropathy is a severe complication of type 1 diabetes and develops in 30% of patients. Currently, it is not possible to identify young patients at risk prior to the development of microalbuminuria (MA) and/or hypertension (HT). OBJECTIVE To study predictors of MA and/or HT in young normoalbuminuric (NA) patients with type 1 diabetes. (More)
  • 1