Nina Alphey

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Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that releases adult male insects homozygous for a dominant, repressible, lethal genetic trait. A dynamic model for the female adult mosquito population, which incorporates(More)
Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populations are clearly needed. The Sterile Insect Technique (SIT) has been successful against agricultural pests, but is not in large-scale use for suppressing or eliminating mosquito populations. Genetic RIDL technology (Release of Insects carrying a(More)
Some proposed genetics-based vector control methods aim to suppress or eliminate a mosquito population in a similar manner to the sterile insect technique. One approach under development in Anopheles mosquitoes uses homing endonuclease genes (HEGs)-selfish genetic elements (inherited at greater than Mendelian rate) that can spread rapidly through a(More)
Genetic vector control strategies to reduce the burden of mosquito-borne diseases Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populations are clearly needed. The Sterile Insect Technique (SIT) is an area-wide method of biological pest control whereby large numbers of a pest insect are bred,(More)
Five Things to Know about Genetically Modified (GM) Insects for Vector Control 1. Why (and how to) use GM vectors for vector control? Vector-borne diseases cause immense suffering and economic damage. Vector control remains a key element of mitigation and control strategies, particularly for pathogens such as dengue viruses for which there are no specific(More)
Development and evaluation of new insect pest management tools is critical for overcoming over-reliance upon, and growing resistance to, synthetic, biological and plant-expressed insecticides. For transgenic crops expressing insecticidal proteins from the bacterium Bacillus thuringiensis (‘Bt crops’) emergence of resistance is slowed by maintaining a(More)
Genetic insect control, such as self-limiting RIDL2 (Release of Insects Carrying a Dominant Lethal) technology, is a development of the sterile insect technique which is proposed to suppress wild populations of a number of major agricultural and public health insect pests. This is achieved by mass rearing and releasing male insects that are homozygous for a(More)
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