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UNLABELLED  : To evaluate the efficacy of autologous platelet rich fibrin in soft tissue healing and bone regeneration in mandibular third molar extraction sockets. METHOD The study was conducted in 20 patients visiting in outpatient department of Oral and Maxillofacial Surgery, requiring extraction of bilateral mandibular third molar, following(More)
Puppet is a configuration management system used by hundreds of organizations to manage thousands of machines. It is designed to automate tasks such as application configuration, service orchestration , VM provisioning, and more. The heart of Puppet is a declarative domain-specific language that specifies a collection of resources (packages, user accounts,(More)
INTRODUCTION Development in plating systems and technical knowledge regarding the osteosynthesis has made open reductions and rigid internal fixation as the most frequently used mode of treatment in facial skeleton fractures. Various modalities for fracture reduction/stabilization during fixation have been mentioned in literature, describing the use of(More)
Despite the advances in the design of antibody–drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(II)-based linker that can re-bridge the inter-chain cysteines in the antibody, post-reduction. The(More)
153 Background: Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancer patients, with a median survival of 13 months and limited treatment options. Recent studies have indicated clinical benefits in TNBC with platinum agents. We designed a novel platinum chemotherapeutic (IO-125), with platinum (II) tethered to cholesterol-based leaving(More)
Despite the advances in the design of antibody-drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the inter-chain cysteines in the antibody, post-reduction. The(More)
Pediatric patients present a unique challenge to maxillofacial surgeons in terms of their treatment planning as well as in their functional and nutritional needs which are different from that of adult patients. Early literature has advocated conservative closed management of pediatric fractures to prevent complications. However recent advances in(More)
The paper introduces a new approach to network routing using the adaptive learning techniques of Ant Colony Optimization (ACO) framework. The proposed algorithm is based on the two ACO algorithms AntNet and Omicron Ant Colony Optimization (OA). In principle, the algorithm uses the mobile agents (ants) to collect information about the network. The ants(More)
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