Nimish Gupta

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Puppet is a configuration management system used by hundreds of organizations to manage thousands of machines. It is designed to automate tasks such as application configuration, service orchestration, VM provisioning, and more. The heart of Puppet is a declarative domain-specific language that specifies a collection of resources (packages, user accounts,(More)
Despite the advances in the design of antibody-drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the inter-chain cysteines in the antibody, post-reduction. The(More)
The paper introduces a new approach to network routing using the adaptive learning techniques of Ant Colony Optimization (ACO) framework. The proposed algorithm is based on the two ACO algorithms AntNet and Omicron Ant Colony Optimization (OA). In principle, the algorithm uses the mobile agents (ants) to collect information about the network. The ants(More)
153 Background: Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancer patients, with a median survival of 13 months and limited treatment options. Recent studies have indicated clinical benefits in TNBC with platinum agents. We designed a novel platinum chemotherapeutic (IO-125), with platinum (II) tethered to cholesterol-based leaving(More)
Invictus Oncology Pvt. Ltd., Delhi-110092, invictusoncology.com India Innovation Research Center, Delhi-11 Department of Chemical Sciences, Indian In Kolkata, Mohanpur-741252, India Health and Biomedical Sciences, Symbiosi India Brigham and Women's Hospital, Harvard M Harvard – MIT Division of Health Sciences USA † Electronic supplementary information(More)
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