BACKGROUND The dynamic properties of microtubules depend on complex nanoscale structural rearrangements in their end regions. Members of the EB1 and XMAP215 protein families interact autonomously with microtubule ends. EB1 recruits several other proteins to growing microtubule ends and has seemingly antagonistic effects on microtubule dynamics: it induces… (More)
Gustafsson (2007) discussion of our paper '4-D-Var or EnKF?' is very stimulating and brings up several interesting and valid points. We completely agree that the most useful question should be 'How can ideas from EnKF and 3–4-D-Var be best com-bined?' In the response to his comments, we point out that many of the ideas originally developed for 4-D-Var can… (More)
In this paper we describe the implementation of a numerical weather forecast model on a massively parallel computer system. This model is a production code used for routine weather forecasting at the meteorological institutes of several European countries. The modiications needed to achieve a data-parallel version of this model without explicit message… (More)
A data-parallel implementation on a SIMD platform of an operational numerical weather forecast model is presented. The performances of two popular numerical techniques within these models are discussed, namely finite difference (gridpoint) methods and spectral methods. In this paper in particular the performance achieved for a full production run is… (More)
Despite significant progress, high-speed live-cell super-resolution studies remain limited to specialized optical setups, generally requiring intense phototoxic illumination. Here, we describe a new analytical approach, super-resolution radial fluctuations (SRRF), provided as a fast graphics processing unit-enabled ImageJ plugin. In the most challenging… (More)
The results presented in this paper are part of a research project to investigate the possibilities to apply massively parallel architectures for numerical weather forecasting. Within numerical weather forecasting several numerical techniques are used to solve the model equations. This paper compares the performance of implementations on a MasPar system of… (More)
A model for F0F1ATP Synthase as two chemically driven ratchets with constant forward rates in opposing directions coupled by an elastic axle in a 'tug of war' is proposed. A Monte-Carlo method is used to simulate the operation of this model to study the rate dependence on the free energy available to the F0 motor and the torsional rigidity of the axle. The… (More)
This paper describes the current status of our research on data parallel implementations of the complete HIRLAM forecast model with both gridpoint and spectral dynamics, on massively parallel architectures. It is part of a research project, that investigates the possibilities to apply parallel computer systems for routine numerical weather forecasting.