Nils Blomqvist

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Current evidence links psychosocial factors to exacerbation of diet-induced atherosclerosis in monkeys via activation of the sympathetic nervous system. However, it is uncertain whether these factors can potentiate initial lesion formation, and do so even in the absence of dietary provocation, and whether any such effects can be prevented by beta-adrenergic(More)
It is stated that in trials where experimental units on different levels (sites, patients, etc.) are employed, the highest level unit should be used as computational unit when computing standard errors and in statistical inference. Using a lower level unit will underestimate the standard error and the level of significance (P-value). A numerical(More)
In studies of treatment effects in clinical trials and longitudinal followup investigations, it is not unusual to inquire as to whether a relationship exists between the change of a variable and its initial value, for example pocket depth Such studies must be carried out with great care, since the results are biassed by the regression towards the mean (RTM)(More)
Whether initial value affects blood pressure change or not is of interest in longitudinal blood pressure studies. The change/initial value relationship is, however, biased by the regression towards the mean phenomenon, as blood pressure measurements contain random errors (short-term intra-individual variation and measurement errors). Two methods (here(More)
The principles of a fully automated potentiometric determination of ionized magnesium in human blood serum are presented. By incorporating a magnesium selective electrode, into a commercially available six channel electrolyte analyzer (Microlyte 6, KONE Instruments, Finland), determination of the biologically-active, ionized fraction of magnesium has been(More)
The relation between change and initial value is of great interest in longitudinal studies. With variables containing random errors (short-term intra-individual variations and measurement errors) the directly computed relation is however, biased by the regression towards the mean phenomenon. Earlier proposed solutions of the problem are unsatisfactory. In(More)
The possibility that lithium affects the conversion of thyroxine to 3,5,3"-triiodothyronine and 3,3',5'-triiodothyronine (reverse triiodothyronine) was studied by measurement of the serum concentractions of these parameters in five patients during the first week of lithium therapy. In three patients there was a decrease in serum thyroxine concentration and(More)
When studying the correlation between the change of a variable during treatment and the value before treatment, random errors (errors of measurement as well as intra-individual biological variation) may yield seriously biased results. In the present work a method to adjust for this bias is presented. The method was applied to data from blood coagulation(More)