Nilofar Mohaideen

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Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We used whole-genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolgus macaques with active, latent or reactivated disease. We sequenced 33 Mtb isolates from nine macaques with(More)
Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based screening has largely proven unsuccessful for antibiotic discovery, we have developed a scalable platform for target(More)
  • Thomas R Ioerger, Theresa O 'malley, Reiling Liao, Theresa O 'malley, Reiling Liao, Kristine M Guinn +18 others
  • 2015
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis" (2013). This work is licensed under a Creative Commons Attribution 4.0 License. Abstract Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to(More)
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