Amresh Shrivastava12
Avinash De Sousa9
Larry Stitt8
Meghana Thakar6
12Amresh Shrivastava
9Avinash De Sousa
8Larry Stitt
6Meghana Thakar
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To identify novel tyrosine kinase substrates that have never been implicated in cancer, we studied the phosphoproteomic changes in the MCF10AT model of breast cancer progression using a combination of phosphotyrosyl affinity enrichment, iTRAQ technology, and LC-MS/MS. Using complementary MALDI- and ESI-based mass spectrometry, 57 unique proteins comprising(More)
Power management techniques for mobile appliances put the components of the systems into low power states to maximize battery life while minimizing the impact on the perceived performance of the devices. Static timeout policies are the state-of-the-art approach for solving power management problems. In this work, we propose adaptive timeout policies as a(More)
  • Lee Yee Choong, Simin Lim, Poh Kuan Chong, Chow Yin Wong, Nilesh Shah, Yoon Pin Lim
  • 2010
BACKGROUND Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer. METHODOLOGY/PRINCIPAL FINDINGS(More)
BACKGROUND It is not clear if the role of antipsychotics in long-term clinical and functional recovery from schizophrenia is correlated. The pattern of use is a major aspect of pharmacotherapy in long-term follow-ups of schizophrenia. The aim of this study was to examine patterns of antipsychotic usage in patients with longstanding psychosis and their(More)
Duration of untreated psychosis (DUP) has emerged as a reliable predictor of outcome but continues to remain under scientific scrutiny. The present study examines the effect of differential periods of DUP on long-term outcome of first episode schizophrenia at Mumbai, India. This research was a prospective, 10-year follow-up naturalistic study. Hospitalized(More)
Thirty patients suffering from schizophrenia (diagnosed as per DSM-IV criteria), for more than 2 years and having predominant negative symptoms were started on risperidone (2-10 mg/day) and were followed up over a period of 16 weeks. The improvement was assessed using PANSS (Positive and Negative Syndrome Scale).During this 16 weeks follow up, it was(More)
Psychiatric polypharmacy refers to the prescription of two or more psychiatric medications concurrently to a patient. It can be categorised as same-class, multi-class, adjunctive, augmentation and total polypharmacy. Despite advances in psychopharmacology and a better understanding of the principles of therapeutics, its practice is increasing rapidly. The(More)
Over the past 50 years, schizophrenia as a disorder has been widely studied across cultures throughout the world. There are differences not only in the symptoms and presentation but also in outcome and prognosis. Various authors have tried to explore and explain such variation but the reasons for this are not always clear. In this paper, we review some of(More)
BACKGROUND A limited number of studies have assessed the pathways to care of patients experiencing psychosis for the first time. Helpline/clinic programs may offer patients who are still functional but have potential for crisis an alternative that is free from judgment. METHODS In this study we report on patient calling a round-the-clock crisis helpline(More)
One negative outcome associated with schizophrenia is a deterioration of cognitive functioning. Little is known about what happens to cognitive abilities in the years following a diagnosis of first-episode schizophrenia. This study assessed the cognitive functioning of 61 individuals with first-episode schizophrenia who showed significant clinical(More)