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Expansion and concatenation of nonmuscle myosin IIA filaments drive cellular contractile system formation during interphase and mitosis
TLDR
Stacks of nonmuscle myosin IIA filaments form by the expansion of single filaments and concatenation of multiple filaments that are dependent on both motor activity and actin filament concentration.
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Molecular and morphological characterization of Indian farmers rice varieties (Oryza sativa L.).
TLDR
Clustering of Indian farmers’ rice varieties according to their genotypes as well as phenotypes revealed the possible linkage or pleiotropic effects of the genomic regions associated with some grain quality traits.
Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes
TLDR
An assay using human cardiomyocytes to monitor sarcomere assembly is developed and it is shown that A-band assembly is dependent on the proper organization of actin filaments and, as such, is also dependent on FHOD3 and myosin IIB.
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Precise tuning of cortical contractility regulates cell shape during cytokinesis
TLDR
A balance between MII paralogs allows a fine-tuning of cortex tension at the polar cortex to maintain cell shape during cytokinesis, with MIIA driving cleavage furrow ingression and bleb formation, and MIIB serving as a stabilizing motor and mediating completion of cytokinesIS.
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Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
TLDR
This study identifies a distinct functional nanoparticle replete with potential circulating biomarkers and therapeutic targets for a host of human diseases, termed supermere.
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Focal adhesions control cleavage furrow shape and spindle tilt during mitosis
TLDR
A population of mitotic focal adhesions (FAs) controls the symmetry of the cleavage furrow and is revealed as a key link between mitotic cell shape and spindle orientation and may have important implications in the understanding stem cell homeostasis and tumorigenesis.
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MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes
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Inhibition of focal adhesion kinase increases myofibril viscosity in cardiac myocytes
TLDR
Inhibition of FAK signaling altered the viscoelastic properties of myofibrils, and resulted in increased viscous damping of my ofibril retraction following laser ablation.
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Myosin IIA drives membrane bleb retraction
TLDR
It is shown that MIIA specifically drives bleb retraction during cytokinesis, and the motor domain and regulation of the nonhelical tailpiece of MIIA both contribute to its ability to drive bleb Retraction.
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The balance between adhesion and contraction during cell division.
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