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Inhaled hyperpolarized helium-3 (3He) gas is a new magnetic resonance (MR) contrast agent that is being used to study lung functionality. To evaluate the total lung ventilation from the hyperpolarized 3He MR images, it is necessary to segment the lung cavities. This is difficult to accomplish using only the hyperpolarized 3He MR images, so traditional(More)
We propose a cell detection and tracking solution using image-level sets computed via threshold decomposition. In contrast to existing methods where manual initialization is required to track individual cells, the proposed approach can automatically identify and track multiple cells by exploiting the shape and intensity characteristics of the cells. The(More)
The problem of identifying and counting rolling leukocytes within intravital microscopy is of both theoretical and practical interest. Currently, methods exist for tracking rolling leukocytes in vivo, but these methods rely on manual detection of the cells. In this paper we propose a technique for accurately detecting rolling leukocytes based on Bayesian(More)
Inflammatory disease is initiated by leukocytes (white blood cells) rolling along the inner surface lining of small blood vessels called postcapillary venules. Studying the number and velocity of rolling leukocytes is essential to understanding and successfully treating inflammatory diseases. Potential inhibitors of leukocyte recruitment can be screened by(More)
A significant medical informatics task is indexing patient databases according to size, location, and other characteristics of brain tumors and edemas, possibly based on magnetic resonance (MR) imagery. This requires segmenting tumors and edemas within images from different MR modalities. To date, automated brain tumor or edema segmentation from MR(More)
In this paper we propose a locally adaptive image threshold technique via variational energy minimization. The novelty of the proposed method is that from an image it automatically computes the weights on the data fidelity and the regularization terms in the energy functional, unlike many other previously proposed variational formulations that require(More)
This paper introduces an active contour or snake-based method for tracking cells within a video sequence. Specifically, we apply our cell tracking techniques to rolling leukocytes observed in vivo (in living animal) from video microscopy. The analysis of leukocyte motion reveals cues about the mechanism of inflammatory disease. To attack the problem of(More)
INTRODUCTION Our objectives were to assess reliability, validity, and time efficiency of semiautomatic segmentation using Segura software of the nasal and pharyngeal airways, against manual segmentation with point-based analysis with color mapping. METHODS Pharyngeal and nasal airways from 10 cone-beam computed tomography image sets were segmented(More)
Image segmentation is an important step in most visual tasks. While convolutional neural networks have shown to perform well on single image segmentation, to our knowledge, no study has been done on leveraging recurrent gated architectures for video segmentation. Accordingly, we propose and implement a novel method for online segmentation of video sequences(More)