Nikos Tsilimingas

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OBJECTIVES We tested whether in vivo nitroglycerin (NTG) treatment causes tyrosine nitration of prostacyclin synthase (PGI(2)-S), one of the nitration targets of peroxynitrite, and whether this may contribute to nitrate tolerance. BACKGROUND Long-term NTG therapy causes tolerance secondary to increased vasoconstrictor sensitivity and increased vascular(More)
INTRODUCTION Histamine is involved in the pathogenesis of numerous diseases and regulates the permeability of different tissues. The aim of this study is to investigate the effects of histamine on the electrophysiology of human parietal pleura and the underlying mechanisms involved. MATERIALS AND METHODS Pleural specimens were obtained from patients(More)
Hyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus. Although the mechanisms underlying this phenomenon are likely to be multifactorial, recent in vivo and in vitro studies have indicated a crucial role of the diacylglycerol (DAG)-protein kinase C (PKC) pathway in mediating this(More)
There is an increasing body of evidence that oxidative stress markedly contributes to endothelial dysfunction and to poor prognosis in patients with coronary artery disease and hypertension. Among many stimuli for oxidative stress in vascular tissue, the role of angiotensin II has been extensively studied. When given acutely, angiotensin II stimulates the(More)
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