Nikos Alexandropoulos

  • Citations Per Year
Learn More
A novel biosensory method has been developed for the determination of various chemical and biological molecules by assessing their electrophysiological interactions with a group of cells and cell components immobilized in a gel matrix that preserves their 'physiological' functions. The method was applied for the detection of: (i) hepatitis C virus in human(More)
The bioelectric recognition assay (BERA) is a novel biosensory method based on a unique combination of a group of cells, their immobilization in a matrix that preserves their physiological functions and the expression of the cell interaction with viruses as a change in electrical properties. A BERA sensor consists of an electroconductive, tube-like probe(More)
The Bioelectric Recognition Assay (BERA) is a whole-cell based biosensing system that detects the electric response of cultured cells, suspended in a gel matrix, to various ligands, which bind to the cell and/or affect its physiology. Previous studies have demonstrated the potential application of this method for rapid, inexpensive detection of viruses in a(More)
A novel miniature cell biosensor detection system for the detection of Hepatis B virus (HBV)-associated antigens and anti-HBV is described. The biosensor is based on "membrane-engineered" Vero fibroblast cells immobilized in an alginate matrix. The membrane-engineering process involved the electroinsertion of anti-HBV specific antibodies (anti-HBs,(More)
S1 The role of gene expression profiling by microarray analysis for prognostic classification of breast cancer MJ van de Vijver Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands Breast Cancer Research 2005, 7(Suppl 1):S1 (DOI 10.1186/bcr1205) Introduction Prognostic and predictive factors play important roles in the treatment(More)
2087 Introduction: Low aqueous solubility of VRL is a high substrate for ATP dependent drug efflux proteins such as MDR-1(Pgp) and MRP2(ABCC2) inserted in plasma membrane of tumor cells.Furthermore,b-tubulin mutations are cross-resistant to VRL. METHODS We treat with MTC such as VRL and dEpoB advanced mammary carcinoma characterised by overexpression of(More)
e19100 Background: We investigate if venom proteome of vipera ammodytes can induce apoptosis in NSCLC. METHODS We developed a large scale expression system with lung cell line (LCL), which we modified genetically by cloning. We expressed cDNA encoding multimodular disintegrin (rMDVA) comprising 3 domains from the venom of vipera ammodytes. The cDNA of(More)
3062 Background: Prophylactic vaccines have no therapeutic capacity for all the women who are already infected with HPV16 and have developed cervical intraepithelial neoplasia (CIN) or cervical cancer. Approximately 300 million women with CIN and cervical cancer will require therapy in the next decades. Thus, there is a great demand for a therapeutic HPV(More)
  • 1