Nikoleta Parahuleva

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OBJECTIVE Atherosclerosis, as an inflammatory disease, is characterized by pathologically altered levels of cytokines. We investigated whether smoking and/or oral contraceptives (OCs) affect the CD40/CD40L plasma levels and expression in young females without other risk factors for atherosclerosis. PATIENTS AND METHODS A case-control single-center design(More)
UNLABELLED Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and the leading cause of oligo/anovulatory infertility. The incidence of PCOS in the population is 5-10% depending on the phenotypic expression of the syndrome as use criteria for diagnosis Anti- Mullerian Hormone may be defined as a glycoprotein(More)
Anti-Mullerian hormone (AMH) is a glycoprotein produced by the granulosa ovarian cells with respect to the regulation of the follicular growth and development. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disturbances affecting 6-7 of women in reproductive age. Women with PCOS exhibit a number of metabolic and endocrine disturbances(More)
INTRODUCTION Contemporary data show that there is a link between insulin resistance and preeclampsia (PE) due to many common features. MATERIAL AND METHODS We examined 90 pregnant women at the clinic of Obstetrics and Gynecology at the University Hospital "St.George". 35 of them were preeclamptic and 55 normotensive. Glucose levels were measured at 0, 1,(More)
Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder which deficiency of the platelet glycoprotein IIb - III a. The disorder usually manifests as severe mucocutaneus bleeding in the chaildhood, menstrual patterns in pubertal--adolescent years, rarely life-threatening. Pregnancy and delivery in patients with TG are very rare and are(More)
Increasing number of studies during the last years reveal that steroid hormone vitamin D not only regulate calcium metabolism but it influences and other biological processes like glucose metabolism, neural function, cardio-vascular and reproductive systems. More and more clinical data suggests that normal plasma vitamin D levels are required for(More)
UNLABELLED Polycystic Ovary Syndrome is the most common endocrine disorder in women of reproductive age, whose final pathogenesis remains unclear. PCOS is a distinctive disorder of follicular growth leading to obstruction of the selection of the dominant follicle, and as a result--arrest at small antral follicles. Anti-Mullerian hormone (AMH) is a(More)
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