Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
- S. Haber, J. Fudge, Nikolaus R. McFarland
- BiologyJournal of Neuroscience
- 15 March 2000
Examination of results from multiple tracing experiments simultaneously demonstrates an interface between different striatal regions via the midbrain dopamine cells that forms an ascending spiral between regions that provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain.
Thalamic Relay Nuclei of the Basal Ganglia Form Both Reciprocal and Nonreciprocal Cortical Connections, Linking Multiple Frontal Cortical Areas
- Nikolaus R. McFarland, S. Haber
- BiologyJournal of Neuroscience
- 15 September 2002
A dual role for VA–VL and MD nuclei is indicated to relay basal ganglia output within specific cortical circuits and to mediate information flow between cortical circuits, suggesting differential regulation of cortical function.
The Concept of the Ventral Striatum in Nonhuman Primates
- S. Haber, Nikolaus R. McFarland
- BiologyAnnals of the New York Academy of Sciences
- 1 June 1999
The afferent connections to the ventral striatum is used to define this region in monkeys and the shell and core subterritories are discussed with respect to their histochemistry and specific connections.
Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate
- M. Chikama, Nikolaus R. McFarland, D. Amaral, S. Haber
- BiologyJournal of Neuroscience
- 15 December 1997
The results show that cytoarchitectonically less differentiated insular regions project to the ventromedial “limbic” part of the ventral striatum, whereas more differentiated (granular)insular regionsProjected to the dorsolateral “sensorimotor” parts of the striatum.
Free-water imaging in Parkinson's disease and atypical parkinsonism.
- P. J. Planetta, Edward Ofori, D. Vaillancourt
- Biology, PsychologyBrain : a journal of neurology
- 1 February 2016
A novel bi-tensor diffusion analysis model was used to indicate that all forms of parkinsonism had elevated free-water in the substantia nigra, and both multiple system atrophy and progressive supranuclear palsy, but not Parkinson's disease, showed a broad network of elevatedFree-water and altered free- water corrected fractional anisotropy that included the basal ganglia, thalamus, and cerebellum.
Convergent Inputs from Thalamic Motor Nuclei and Frontal Cortical Areas to the Dorsal Striatum in the Primate
- Nikolaus R. McFarland, S. Haber
- Biology, PsychologyJournal of Neuroscience
- 15 May 2000
This study examines the organization of VA/VL thalamic inputs to the dorsal “motor” striatum to determine how this afferent projection is organized with respect to corticostriatal afferents from motor, premotor, and cingulate motor areas.
Organization of thalamic projections to the ventral striatum in the primate
- J. Giménez-Amaya, Nikolaus R. McFarland, S. De Las Heras, S. Haber
- BiologyThe Journal of comparative neurology
- 27 March 1995
The organization of the thalamic projections to the ventral striatum in the primate brain is explored by means of wheat germ agglutinin conjugated to horseradish peroxidase (WGA‐HRP) and Lucifer yellow (LY) retrograde tracer techniques.
&agr;-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease
- Nikolaus R. McFarland, Z. Fan, P. McLean
- BiologyJournal of Neuropathology and Experimental…
- 1 May 2009
It is suggested that injections of both S129 phosphorylation mutants result in dopaminergic neurotoxicity similar to wt injections, and further study is needed to clarify the effects of these S129 mutants and &agr;-synuclein phosphorylated in mammalian systems.
The Place of the Thalamus in Frontal Cortical-Basal Ganglia Circuits
- S. Haber, Nikolaus R. McFarland
- Biology, PsychologyThe Neuroscientist
- 1 August 2001
This work has shown that the corticothalamic projection is important for the dynamics of the thalamo-cortical processing and the relay nuclei that carry basal ganglia output to the cortex have recently been shown to project back to the basal Ganglia directly.
A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
- A. McGarry, M. Mcdermott, M. Cudkowicz
- MedicineNeurology
- 10 January 2017
These data do not justify use of CoQ as a treatment to slow functional decline in HD, and Class I evidence that CoQ does not slow the progressive functional decline of patients with HD is provided.
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