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  • Susan Lynne McGovern, Emilia Caselli, Nikolaus Grigorieff, Brian K. Shoichet
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2002 (First Publication: 1 April 2002)
  • High-throughput and virtual screening are widely used to discover novel leads for drug design. On examination, many screening hits appear non-drug-like: they act noncompetitively, show littleContinue Reading
  • Xing Zhang, Ethan C. Settembre, +4 authors Nikolaus Grigorieff
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2008 (First Publication: 12 February 2008)
  • Electron cryomicroscopy (cryo-EM) yields images of macromolecular assemblies and their components, from which 3D structures can be determined, by using an image processing method commonly known asContinue Reading