Nikolaus E Wolter

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OBJECTIVES Mediated by the medial olivocochlear system (MOCS), distortion product otoacoustic emission (DPOAE) levels are reduced by presentation of contralateral acoustic stimuli. Such acoustic signals can also evoke a middle ear muscle reflex (MEMR) that also attenuates recorded DPOAE levels. Our aim is to clearly differentiate these two inhibitory(More)
Neuroblastoma (NB) is a pediatric tumor of the sympathetic nervous system, which is often associated with elevated catecholamines. More than half of patients with metastatic NB relapse and survival is extremely poor with current therapies. In a high-throughput screen of FDA-approved drugs we identified anti-NB activity for the nonselective β-adrenergic(More)
OBJECTIVE To determine the role of vestibular and balance dysfunction in children with cochlear implant (CI) failure. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Thirty-five children with CI failure were compared to 165 children who did not experience CI failure. MAIN OUTCOME MEASURES Vestibular function was(More)
OBJECTIVES 1) To determine if bilateral vestibular dysfunction can be predicted by performance on standardized balance tasks in children with sensorineural hearing loss (SNHL) and cochlear implants (CI). 2) To provide clinical recommendations for screening for vestibular impairment in children with SNHL. STUDY DESIGN Retrospective cohort study. SETTING(More)
OBJECTIVE To determine if children with unilateral sensorineural hearing loss (UHL) demonstrate impaired balance compared with their normal hearing (NH) peers. STUDY DESIGN Prospective, case-control study. METHODS Balance was assessed in14 UHL and 14 NH children using the Bruininks-Oseretsky Test-2 (BOT-2) and time to fall (TTF) in an immersive,(More)
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