Nikolaus E Wolter

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OBJECTIVE Otitis media with effusion (OME) in children with primary ciliary dyskinesia (PCD) is recurrent and persistent and presents a complex clinical problem for otolaryngologists. We sought to review the otological presentation of children with PCD treated medically and surgically and to compare audiological outcomes and complications of surgical and(More)
Neuroblastoma (NB) is a pediatric tumor of the sympathetic nervous system, which is often associated with elevated catecholamines. More than half of patients with metastatic NB relapse and survival is extremely poor with current therapies. In a high-throughput screen of FDA-approved drugs we identified anti-NB activity for the nonselective β-adrenergic(More)
OBJECTIVES Mediated by the medial olivocochlear system (MOCS), distortion product otoacoustic emission (DPOAE) levels are reduced by presentation of contralateral acoustic stimuli. Such acoustic signals can also evoke a middle ear muscle reflex (MEMR) that also attenuates recorded DPOAE levels. Our aim is to clearly differentiate these two inhibitory(More)
OBJECTIVE To investigate propranolol as a novel treatment for head and neck squamous cell carcinoma (HNSCC) in vitro. METHODS HNSCC cell lines were cultured and treated with propranolol alone and in combination with cisplatin or γ-irradiation. The alamarBlue assay was performed to assess cell viability, and apoptosis was confirmed via Western immunoblot(More)
Middle ear aneurysms are rare and difficult to treat. An innovative, parent vessel-preserving, aneurysm occlusion stent is a treatment alternative. It redirects blood flow away from the aneurysm, resulting in stasis within, and ultimate aneurysm thrombosis. Concurrent coiling is not needed with this stent, eliminating the risk of coils extruding or(More)
AFKBP65 (65-kDa FK506-binding protein) is an endoplasmic reticulum (ER)-localized peptidyl-prolyl cis-trans isomerase predicted to play a role in the folding and trafficking of secretory proteins. In previous studies, we have shown that FKBP65 is developmentally regulated and associates with the extracellular matrix protein, tropoelastin, during its(More)
OBJECTIVE (1) Compare the non-device-related costs of bilateral simultaneous cochlear implantation (BSiCI) vs. unilateral, and (2) establish a dollar amount for potential cost savings in direct costs for BSiCI vs. sequential cochlear implantation (CI). METHODS Data from all CI cases performed during the fiscal year 2010-2011 were retrospectively reviewed(More)
OBJECTIVES/HYPOTHESIS To describe our experience with the use of intralesional corticosteroid injection and dilatation (ILCD) in the management of subglottic stenosis (SGS). STUDY DESIGN Retrospective chart review. METHODS A retrospective chart review was performed of all patients with SGS requiring ILCD, from 2003 to 2008, at the Department of(More)
OBJECTIVE To determine the role of vestibular and balance dysfunction in children with cochlear implant (CI) failure. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Thirty-five children with CI failure were compared to 165 children who did not experience CI failure. MAIN OUTCOME MEASURES Vestibular function was(More)