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STUDY DESIGN An experimental study of cardiovascular complications that arise during vertebroplasty was conducted. OBJECTIVE To investigate the sequential occurrence of fat embolism and hypotension during vertebroplasty. SUMMARY OF BACKGROUND DATA Vertebroplasty, the augmentation of vertebrae with polymethylmethacrylate, is a technique for treating(More)
Vertebral cement augmentation is reported to be a safe and effective technique for providing stabilization and pain relief. However, adjacent intervertebral discs may be at risk of accelerated degeneration as a result of aggravated nutritional constraints. Therefore, we investigated the effects of injecting polymethylmethacrylate (PMMA) into three adjacent(More)
BACKGROUND CONTEXT Neuropathic (Charcot) spinal arthropathy (CSA) is a rare but progressive and severe degenerative disease that develops in the absence of deep sensation, for example, after spinal cord injury. The diagnosis of CSA is often delayed as a result of the late onset or slow progression of the disease and the nonspecific nature of the reported(More)
STUDY DESIGN An experimental study of cardiovascular complications arising during vertebroplasty (VP) of multiple levels in sheep. OBJECTIVES To investigate the effect of pressurizing vertebral bodies during VP using different materials in the development of fat embolism (FE) and any associated cardiovascular changes. SUMMARY OF BACKGROUND DATA(More)
STUDY DESIGN Experimental study of temperature profiles during vertebroplasty. OBJECTIVES To define accurate temperature profiles during vertebroplasty in an in vivo animal model. SUMMARY OF BACKGROUND DATA Controversy still exists whether vertebroplasty achieves its analgesic effect by stabilizing fracture fragments or due to thermal damage of sensory(More)
MMP28 (epilysin) is a recently discovered member of the MMP (matrix metalloproteinase) family that is, amongst others, expressed in osteoarthritic cartilage and intervertebral disc (IVD) tissue. In this study the hypothesis that increased expression of MMP28 correlates with higher grades of degeneration and is stimulated by the presence of proinflammatory(More)
BACKGROUND Fat embolism (FE), the release of bone marrow contents into the circulation and the subsequent cardiovascular changes, is still a potentially fatal com-plication during orthopedic surgery. Different causative factors have been suggested, but the exact pathomechanism of FE still remains unclear. We investigated the role of polymethylmethacrylate(More)
Research efforts aim at enhancing early osseointegration of cementless implants to improve early fixation and, thus, reduce the risk of loosening. The aim of the present study was to investigate whether bone morphogenetic protein (BMP) 2 had a positive effect on the osseointegration of hydroxyapatite-coated implants. Hydroxyapatite (HA) implants (perforated(More)
BACKGROUND Intraoperative cardiovascular deterioration as a result of pulmonary embolization of bone marrow fat is a potentially serious complication during vertebroplasty. The release of fatty material and thromboplastin from the bone marrow cavity during vertebroplasty may activate the coagulation cascade resulting in thrombogenesis, and pharmacological(More)