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Myeloproliferation with prominent eosinophilia is associated with rearrangements of PDGFR-A or -B. The most common rearrangement is FIP1L1-PDGFRA (FP). The majority of patients with PDGFR-rearranged(More)
The idiopathic hypereosinophilic syndrome (HES) and chronic eosinophilic leukemia (CEL) are characterized by unexplained, persistent hypereosinophilia. Responses of HES/CEL to treatment with imatinib(More)