Nikolas P. Papadopoulos

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

Peter C. Maisonpierre, C. Raman Suri, +11 authors G. D. Yancopoulos
Science
1997

Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2… (More)

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen).

J P Bousquet, Nikolai Khaltaev, +93 authors D. Williams
Allergy
2008

J. Bousquet, N. Khaltaev, A. A. Cruz, J. Denburg, W. J. Fokkens, A. Togias, T. Zuberbier, C. E. Baena-Cagnani, G. W. Canonica, C. van Weel, I. Agache, N. A t-Khaled, C. Bachert, M. S. Blaiss, S.… (More)

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.

Nick Nicolaides, Nikolas P. Papadopoulos, +7 authors Chris M Fraser
Nature
1994

Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease.… (More)

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.

Ivan B Lobov, Ruth Renard, +4 authors Sandra Wiegand
Proceedings of the National Academy of Sciences…
2007

Genetic deletion studies have shown that haploinsufficiency of Delta-like ligand (Dll) 4, a transmembrane ligand for the Notch family of receptors, results in major vascular defects and embryonic… (More)

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

Fredrick S. Leach, Nick Nicolaides, +7 authors Minna Nyström-Lahti
Cell
1993

Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain alterations in… (More)

Mutation of a mutL homolog in hereditary colon cancer.

Nikolas P. Papadopoulos, Nick Nicolaides, +7 authors M. D. Adams
Science
1994

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from… (More)

The molecular basis of Turcot's syndrome.

S. R. Hamilton, B. Liu, +7 authors Bernard Têtu
The New England journal of medicine
1995

BACKGROUND Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the molecular level. … (More)

A public database for gene expression in human cancers.

A. Lal, Alex E. Lash, +12 authors Gregory Joseph Riggins
Cancer research
1999

A public database, SAGEmap, was created as a component of the Cancer Genome Anatomy Project to provide a central location for depositing, retrieving, and analyzing human gene expression data. This… (More)

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

John D. Carpten, Nina N. Nupponen, +38 authors Jeffrey M. Trent
Nature Genetics
2002

Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about inherited factors that influence its genetic predisposition. Here we… (More)

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

David Valenzuela, J. A. Griffiths, +12 authors G. D. Yancopoulos
Proceedings of the National Academy of Sciences…
1999

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins… (More)

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