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We study the capability of the MAGIC telescope to observe under moderate 3 moonlight. TeV γ-ray signals from the Crab nebula were detected with the MAGIC telescope during periods when the Moon was above the horizon and during twilight. This was accomplished by increasing the trigger discriminator thresholds. No change is necessary in the high voltage(More)
We report about very high energy (VHE) γ-ray observations of the Crab Nebula with the MAGIC telescope. The γ-ray flux from the nebula was measured between 60 GeV and 9 TeV. The energy spectrum can be described with a curved power law dF dE = f 0 (E/300 GeV) (a+b log 10 (E/300 GeV)) with a flux normalization f 0 of (6.0 ± 0.2 stat) × 10 −10 cm −2 s −1 TeV −1(More)
We report on the discovery of Very High Energy (VHE) γ-ray emission from the BL Lacertae object 1ES 1011+496. The observation was triggered by an optical outburst in March 2007 and the source was observed with the MAGIC telescope from March to May 2007. Observing for 18.7 hr, we find an excess of 6.2 σ with an integrated flux above 200 GeV of (1.58±0.32) ·(More)
All but three (M87, BL Lac and 3C 279) extragalactic sources detected so far at very high energy (VHE) γ-rays belong to the class of high-frequency peaked BL Lac (HBL) objects. This suggested to us a systematic scan of candidate sources with the MAGIC telescope, based on the compilation of X-ray blazars by Donato et al. (2001). The observations took place(More)
The MAGIC collaboration has observed very high energy gamma ray emission from the AGN 1ES 2344+514. A gamma-ray signal corresponding to an 11σ excess and an integral flux of (2.38 ± 0.30 stat ± 0.70 syst) × 10 −11 cm −2 s −1 above 200 GeV has been obtained from 23.1 hours of data taking between 2005 August 3 and 2006 January 1. The data confirm the(More)
We used the free-energy perturbation (FEP) method in quantum mechanics/molecular mechanics (QM/MM) calculations to compute the free-energy profile of the hydroxylation reaction in the enzyme p-hydroxybenzoate hydroxylase (PHBH). k statistics were employed to analyze the FEP sampling including estimation of the sampling error. Various approximations of the(More)
The self-consistent-charge density functional tight binding (SCC-DFTB) method is compared with other semiempirical methods (MNDO, AM1, PM3, OM1, OM2, OM3). Despite the differences in the underlying philosophy and derivation, these methods share many common features. Systematic evaluations of their performance are reported for standard test sets that are in(More)
Microquasars are binary star systems with relativistic radio-emitting jets. They are potential sources of cosmic rays and can be used to elucidate the physics of relativistic jets. We report the detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I 61 + 303. Six orbital cycles were recorded. Several detections occur(More)
An earlier experimental study, which involved the directed evolution of enantioselective lipase variants from Pseudomonas aeruginosa as catalysts in the hydrolytic kinetic resolution of 2-methyl-decanoic acid p-nitrophenyl ester, provided a mutant with six mutations. Consequently, the selectivity factor was found to increase from E = 1.1 for the wild-type(More)
Molecular modeling with classical force-fields has been used to study the reactant complex and the tetrahedral intermediate in lipase-catalyzed ester hydrolysis in 20 enzyme/substrate combinations. The R and S enantiomers of alpha-methyldecanoic acid ester served as substrates for the wild-type lipase from Pseudomonas aeruginosa and nine selected mutants.(More)