Nikolai L Shimanovskii

Learn More
Among the targets of the steroid hormones are mitochondria, which as the main source of reactive oxygen species (ROS) in the cell play a central role in the development of various pathologies. We studied the effect of progesterone and its synthetic analogues on mitochondrial ROS production. It was found that progesterone activates the formation of(More)
Low-intensity electromagnetic field (12.6 cm, 2375 MHz, power density 1 mW/cm2) produced retrograde amnesia in the rat passive avoidance test. No effect was registered of microwave irradiation on the open field behavior and the pain sensitivity. Functional activity of the m-cholinergic receptors decreased, but their number increased in the brain cortex. It(More)
The influence of progesterone and its synthetic analogues on the induction of the Ca(2+)-dependent mitochondrial permeability transition pore (MPTP) has been studied. The novel synthetic analogue of progesterone 17a-acetoxy-3b-butanoyloxy-6-methyl-pregna-4,6-diene-20-on (buterol) was compared with progesterone and medroxyprogesterone acetate (MPA). It was(More)
The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without(More)
Data available in the literature on the pharmacological activity of quercetin and its derivatives, which possess various biological properties including antihypertensive and neurotropic activity, are reviewed. The mechanisms of these effects and results of clinical trials are considered and prospects for the clinical use of quercetin and its derivatives are(More)
The authors present results obtained in a complex study of 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-on (ABMP). ABMP was shown to differ from existing analogues by high gestagen activity and prolonged action. The substance does not possess androgenic or mineralocorticoid activity, is not toxic when used in high doses, and possesses(More)
The role of thiols of the outer and the inner membranes of mitochondria in the regulation of generation of reactive oxygen species (ROS) has been studied. It was found that N-ethylmaleimide (NEM), which penetrates through the mitochondrial membrane and binds thiols to form thioesters, at concentrations from 20 to 250 μM activates the production of(More)
Possible applications of magnetic relaxation to the studies of microstructures of water-protein layer of spin-labelled proteins and enzymes are analyzed on lyzozymes taken as an example. It is shown that the effective time of correlation of dipole-dipole interaction of the complex spin label--water proton (Tauc), as well as thermodynamic parameters Eeff.(More)
New results concerning the mechanisms of biphosphonate action on malignant metastasis are described, which justify an increase in the use of biphosphonates not only for the treatment of malignancies, but for prophylaxis of malignant neoplasm development as well. Data on the relationship between the pharmacological effect of biphosphonates and their chemical(More)