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Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. These pathological features manifest behaviorally as positive symptoms (including hallucinations, delusions and thought disorder), negative symptoms (such as social(More)
Glutamate neurotransmission has been considered as one of pathogenetic factors of schizophrenia though all antipsychotics widely used in modern psychiatric practice are dopamine antagonists. LY2140023 is a selective agonist for metabotropic glutamate 2/3 (mGlu2/3) receptors with antipsychotic effect. In the present study, we have assessed clinical efficacy(More)
The authors consider the general conception of the pathogenesis of mental diseases based on the disruption of interactions between local neuronal networks. The development of mental disorders provoked by environmental factors is thought to disturb the activity of small groups of neurons with genetically determined module activity. It is hypothesized that(More)
We present a review of existing models for evaluating treatment-resistant depression (TRD). Their main advantages and drawbacks are identified, and the potential for using them in clinical practice is assessed. A new spectral model of TRD is presented, which considers the clinical spectrum of types (variants) of TRD; this model requires further development.
features of an individual's circadian rhythms can have significant influences on the nature of his or her adaptation to study, work, and rest schedules [1]. " Morning " people (" larks ") find it easier to adapt to work starting in the morning hours, when their work capacity is close to maximal , while " night " people (" owls ") often have to adapt to(More)
Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. These pathological features manifest behaviorally as positive symptoms (including hallucinations, delusions and thought disorder), negative symptoms (such as social(More)
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