Nikolai G Khlebtsov

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Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider(More)
Functionalized gold nanoparticles with controlled geometrical and optical properties are the subject of intensive studies and biomedical applications, including genomics, biosensorics, immunoassays, clinical chemistry, laser phototherapy of cancer cells and tumors, the targeted delivery of drugs, DNA and antigens, optical bioimaging and the monitoring of(More)
The bacterial action of gentamicin and that of a mixture of gentamicin and 15-nm colloidal-gold particles on Escherichia coli K12 was examined by the agar-well-diffusion method, enumeration of colony-forming units, and turbidimetry. Addition of gentamicin to colloidal gold changed the gold color and extinction spectrum. Within the experimental errors, there(More)
1012 T Th he er ra an no os st ti ic cs s In our paper [1], the Figure 6 legend should be corrected as follows: (b) TEM image of the same bacteria after a special washing procedure and simultaneous labeling with a mixture of O-specific conjugates (50-nm Au−Ag nanocages + anti-LPS antibodies) and H-specific conjugates (15-nm GNPs + anti-PFL antibodies).
Gold nanoparticles (AuNPs) of different size and shape are widely used as photosensitizers for cancer diagnostics and plasmonic photothermal (PPT)/photodynamic (PDT) therapy, as nanocarriers for drug delivery and laser-mediated pathogen killing, even the underlying mechanisms of treatment effects remain poorly understood. There is a need in analyzing and(More)
We describe a new approach to the fabrication of surface-enhanced Raman scattering (SERS) substrates using gold nanorod (GNR) nanopowders to prepare concentrated GNR sols, followed by their deposition on an opal-like photonic crystal (OPC) film formed on a silicon wafer. For comparative experiments, we also prepared GNR assemblies on plain silicon wafers.(More)
The effects of gold nanorods to internal organs and liver tumors were studied in rats with combined pathology ‐ alloxan diabetes and transplanted liver tumors at single intravenous administration. The evaluation of morphological and functional changes and gold biodistribution in the internal organs and transplanted liver tumor were conducted. It was found(More)
We report on the first application of silica-gold nanoshells to a solid-phase dot immunoassay. The assay principle is based on staining of a drop (1 ll) analyte on a nitrocellulose membrane strip by using silica/gold nanoshells conjugated with biospecific probing molecules. Experimental example is human IgG (hIgG, target molecules) and protein A (probing(More)
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