Nikola Bradic

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INTRODUCTION The incidence of Acute Kidney Injury is nowadays high in critically ill patients. Its etiology is multifactorial and a primary role is played by low cardiac output syndrome. Everything targeted to normalize cardiac output should increase the renal perfusion and abolish the secondary vasoconstriction. Levosimendan is a calcium sensitizer drug(More)
Objective Levosimendan, calcium sensitizer, induces contractility by binding to troponin C without increasing intracellu-lar calcium concentration. We tested the hypothesis that levosimendan could produce early and prolonged beneficial effect on left ventricular (LV) systolic function in patients with normal LV function undergoing off-pump coronary artery(More)
Objective To evaluate a cardioprotective effect of sevoflurane in patients underwent off-pump coronary artery bypass grafting with normal preoperative left ventricular function. Methods Study included 48 patients induced in anesthesia with 8 vol.% sevoflurane within high 100% oxygen flow (5 L/min). Patients randomized into two groups: sevoflurane group (n =(More)
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