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- Changsuek Yon, Tadahisa Teramoto, +4 authors Rugmani Padmanabhan
- The Journal of biological chemistry
- 2005
Dengue virus type 2 (DEN2), a member of the Flaviviridae family, is a re-emerging human pathogen of global significance. DEN2 nonstructural protein 3 (NS3) has a serine protease domain (NS3-pro) and… (More)
Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency.
- Niklaus H. Mueller, Donald H. Gilden, Randall J. Cohrs, Ravi Mahalingam, Maria A Nagel
- Neurologic clinics
- 2008
Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which virus becomes latent in cranial nerve ganglia, dorsal… (More)
- Niklaus H. Mueller, Nagarajan Pattabiraman, Camilo Ansarah-Sobrinho, Prasanth Viswanathan, Theodore C Pierson, Rugmani Padmanabhan
- Antimicrobial agents and chemotherapy
- 2008
West Nile virus and dengue virus are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics are currently available. These viruses… (More)
- Niklaus H. Mueller, Changsuek Yon, Vannakambadi K. Ganesh, Rugmani Padmanabhan
- The international journal of biochemistry & cell…
- 2007
West Nile virus (WNV), a mosquito-borne member of Flaviviridae, is a human pathogen causing widespread disease for which there is no vaccine or chemotherapy. The two-component viral serine protease… (More)
- Manolya D Ezgimen, Niklaus H. Mueller, Tadahisa Teramoto, Radhakrishnan Padmanabhan
- Bioorganic & medicinal chemistry
- 2009
Detergents such as Triton X-100 are often used in drug discovery research to weed out small molecule promiscuous and non-specific inhibitors which act by aggregation in solution and undesirable… (More)
- Suzanne M. Tomlinson, Robert D. Malmstrom, Andrew Russo, Niklaus H. Mueller, Yuan-Ping Pang, Stanley J. Watowich
- Antiviral research
- 2009
Dengue virus belongs to the family Flaviviridae and is a major emerging pathogen for which the development of vaccines and antiviral therapy has seen little success. The NS3 viral protease is a… (More)
- Don Gilden, Maria A Nagel, +4 authors Randall J. Cohrs
- Future neurology
- 2009
A declining cell-mediated immunity to varicella zoster virus (VZV) with advancing age or immunosuppression results in virus reactivation from latently infected human ganglia anywhere along the… (More)
- Karen L Christopher, Michelle G. Pedler, Biehuoy Shieh, David A. Ammar, Jonathan Mark Petrash, Niklaus H. Mueller
- Biochimica et biophysica acta
- 2014
In addition to their key role as structural lens proteins, α-crystallins also appear to confer protection against many eye diseases, including cataract, retinitis pigmentosa, and macular… (More)
- Niklaus H. Mueller, David A. Ammar, Jonathan Mark Petrash
- Investigative ophthalmology & visual science
- 2013
PURPOSE
The prevalence of cataract increases with age. Conversely, the abundance of native α-crystallin diminishes with age and cataract development. We hypothesize replenishing lens α-crystallin may… (More)