Niklas Wallentin

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PURPOSE To study lens epithelial cell (LEC) regulation after experimental cataract surgery in rabbits. The effect of aqueous humor (AqH) on LECs in vitro was investigated and the AqH concentrations of basic fibroblast growth factor (bFGF) and transforming growth factor-beta (TGF-beta) were determined. METHODS Aqueous humor was aspirated immediately(More)
PURPOSE The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation activity were determined. METHODS AqH(More)
PURPOSE To determine whether an increased or reduced inflammatory response following cataract surgery influences the development of after-cataract. SETTING Department of Preclinical Ophthalmology, Pharmacia, Uppsala, Sweden. METHODS Rabbits that had had cataract surgery were given endotoxin, ovalbumin, dexamethasone, or diclofenac. Aqueous humor,(More)
PURPOSE It is debated whether the inflammatory reaction that follows cataract surgery is important in the development of after-cataract. The aim of the present investigation was to study if reduction of the early inflammatory process had any effect on the development of after-cataract in the rabbit. METHODS Rabbits were divided into 3 groups: 1) no(More)
RESULTS. Aqueous humor collected after surgery triggered LEC growth on each occasion, except on (postoperative) day 30, in contrast to the effect of normal AqH. Lens epithelial cell proliferation peaked on day 1, displaying a sixfold increase. The bFGF concentration in AqH increased 6to 10-fold after surgery and remained high throughout the experimental(More)
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