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We describe three experiments that explore the real-time access of verb-argument structures in a group of normal control subjects, a group of Broca's aphasic patients, and a group of Wernicke's aphasic patients. Specifically, we examine whether our subjects exhaustively access the thematic representations of verbs in active, passive, cleft-subject, and(More)
OBJECTIVES Perforation of the Schneiderian membrane (maxillary sinus mucosa) is a common complication of maxillary sinus graft procedures. Membrane perforation increases the chance of postoperative sinusitis and endangers graft as well as implant survival. The aim of the present study was to explore the mechanical properties of the Schneiderian membrane. (More)
BACKGROUND Surgical pulmonary endarterectomy is the preferred treatment for chronic thromboembolic pulmonary hypertension. Persistent pulmonary hypertension after pulmonary endarterectomy has been recognized as a major determinant of poor outcome. We tested whether acute vasoreactivity identifies chronic thromboembolic pulmonary hypertension patients prone(More)
Previous studies have provided suggestive evidence for an interaction between ras activation and signalling pathways involved in agonist-stimulated arachidonic acid release in a variety of cell systems. In order to clarify this interaction, we have measured epidermal growth factor (EGF)-stimulated arachidonic acid release in rat-1 fibroblasts transfected(More)
Arachidonic acid release in cells highly over expressing cytosolic phospholipase A2 has been attributed to mitogen-activated protein kinase phosphorylation of cytosolic phospholipase A2 on serine-505. To investigate the role of cytosolic phospholipase A2 in cellular physiology, we attempted to inhibit cytosolic phospholipase A2 in the intact cell employing(More)
The binding of epidermal growth factor (EGF) to its receptor induces tyrosine phosphorylation of phospholipase C gamma (PLC gamma), which appears to be necessary for its activation leading to phosphatidyl inositol (PI) hydrolysis. Moreover, EGF-receptor (EGF-R) activation and autophosphorylation results in binding of PLC gamma to the tyrosine phosphorylated(More)
A monoclonal antibody (PL/IM 430), previously found to inhibit the uptake of Ca2+ into highly purified platelet intracellular membrane vesicles (Hack, N., Wilkinson, J.M. and Crawford, N. 1988, Biochem. J. 250, 355-361) has been introduced into saponin-permeabilised platelets. At a saponin concentration (20-25 micrograms/ml) commensurate with total LDH(More)
Previous studies by Roth & Majerus [J. Clin. Invest. (1975) 56, 624-632] showed that exposure of platelets to [acetyl-14C]aspirin resulted in the radioactive labelling of three polypeptides, two of which were in the cytosol and not saturable, whilst the third was located in particulate material, and was saturated at 30 microM-aspirin. By using high voltage(More)
µTOSS is an R package providing an open source, easy-to-extend platform for multiple hypothesis testing (MHT), one of the most active research fields in statistics over the last 10-15 years. Its first motivation is to establish a common platform and standardization for MHT procedures at large. The µTOSS software has been designed and written in the(More)