Nikki K. Lytle
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent… Expand
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
- Xuefeng Wu, W. Zhang, +14 authors M. Karin
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 4 September 2014
Significance We demonstrate that ubiquitin-conjugating enzyme Ubc13, whose expression is elevated in primary and metastatic breast cancer (BCa), promotes metastatic spread of BCa cells by controlling… Expand
CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Acute myelogenous leukemia (AML) is an aggressive disease associated with drug resistance and relapse. To improve therapeutic strategies, it is critical to better understand the mechanisms that… Expand
Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Cell state reprogramming during tumor progression complicates accurate diagnosis, compromises therapeutic effectiveness, and fuels metastatic dissemination. We used chromatin accessibility assays and… Expand
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?
Astrogliosis and associated dysfunction of adenosine homeostasis are pathological hallmarks of the epileptic brain and thought to contribute to seizure generation in epilepsy. The authors… Expand
Stem cell fate in cancer growth, progression and therapy resistance
Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a key scientific and… Expand
Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Pancreatic intraepithelial neoplasia (PanIN) is a premalignant lesion that can progress to pancreatic ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical… Expand
Caffeine prevents acute mortality after TBI in rats without increased morbidity
Severe traumatic brain injury (TBI) is associated with a high incidence of acute mortality followed by chronic alteration of homeostatic network activity that includes the emergence of posttraumatic… Expand
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
- Nikki K. Lytle, L. P. Ferguson, N. Rajbhandari, Kathryn Gilroy, T. Reya
- Biology, Medicine
- 18 April 2019
Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to map… Expand
CD 98-mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia
Jeevisha Bajaj1,2,3,4,†, Takaaki Konuma1,2,3,4,†, Nikki K. Lytle1,2,3,4, Hyog Young Kwon1,2,3,4, Jailal N. Ablack4, Joseph M. Cantor4, David Rizzieri5, Charles Chuah6, Vivian G. Oehler7, Elizabeth H.… Expand