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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequentExpand
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Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Significance We demonstrate that ubiquitin-conjugating enzyme Ubc13, whose expression is elevated in primary and metastatic breast cancer (BCa), promotes metastatic spread of BCa cells by controllingExpand
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CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Acute myelogenous leukemia (AML) is an aggressive disease associated with drug resistance and relapse. To improve therapeutic strategies, it is critical to better understand the mechanisms thatExpand
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Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Cell state reprogramming during tumor progression complicates accurate diagnosis, compromises therapeutic effectiveness, and fuels metastatic dissemination. We used chromatin accessibility assays andExpand
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Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?
Astrogliosis and associated dysfunction of adenosine homeostasis are pathological hallmarks of the epileptic brain and thought to contribute to seizure generation in epilepsy. The authorsExpand
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Stem cell fate in cancer growth, progression and therapy resistance
Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a key scientific andExpand
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Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Pancreatic intraepithelial neoplasia (PanIN) is a premalignant lesion that can progress to pancreatic ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinicalExpand
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Caffeine prevents acute mortality after TBI in rats without increased morbidity
Severe traumatic brain injury (TBI) is associated with a high incidence of acute mortality followed by chronic alteration of homeostatic network activity that includes the emergence of posttraumaticExpand
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A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to mapExpand
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CD 98-mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia
Jeevisha Bajaj1,2,3,4,†, Takaaki Konuma1,2,3,4,†, Nikki K. Lytle1,2,3,4, Hyog Young Kwon1,2,3,4, Jailal N. Ablack4, Joseph M. Cantor4, David Rizzieri5, Charles Chuah6, Vivian G. Oehler7, Elizabeth H.Expand
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