Nikita V. Ivanisenko

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As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real challenge. The HCV subgenomic replicon-containing cells are widely used for experimental studies of the HCV genome replication mechanisms, for drug testing in vitro and in studies of HCV drug resistance.(More)
Sufficient knowledge of molecular and genetic interactions, which comprise the entire basis of the functioning of living systems, is one of the necessary requirements for successfully answering almost any research question in the field of biology and medicine. To date, more than 24 million scientific papers can be found in PubMed, with many of them(More)
Inhibition of the activity of the tumor necrosis factor (TNF) has become the main strategy for treating inflammatory diseases. The orthopoxvirus TNF-binding proteins can bind and efficiently neutralize TNF. To analyze the mechanisms of the interaction between human (hTNF) or mouse (mTNF) TNF and the cowpox virus N-terminal binding domain (TNFBD-CPXV), also(More)
The identification of new effective apoptosis inhibitors plays an important role in the development of drugs for the treatment of various disorders, including neurogenerative diseases. Apoptosis is initiated via the formation of macromolecular protein complexes. These complexes exert the activation of caspases, which are key regulators and executors of(More)
CD95 is one of the best-studied members of the death receptor family. Activation of CD95 leads to the induction of the cell death program, apoptosis, via formation of the death-inducing signaling complex (DISC). The Fas-Associated Death Domain (FADD) is a key adaptor protein in the formation of the CD95 DISC and activation of procaspase 8 in the receptor(More)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, which affects motor neurons in the brain and spinal cord and leads to patients’ death. One of the causes of motor neuron degeneration and death is the formation of intracellular aggregates by a mutant SOD1 protein. Recently, it has been shown that the survival time of ALS patients with a(More)
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