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The tentacle withdrawal reflex in the terrestrial snail Helix aspersa involves bending and retraction of the tentacles. When elicited by mechanical stimulation of the tentacle, the reflex is mediated by the conjoint action of the central and peripheral nervous systems. The neural circuit underlying the stimulus-response pathways was studied in vitro using a(More)
Menthol and related compounds were investigated for modulation of recombinant human gamma-aminobutyric acid type A (GABA(A), alpha(1)beta(2)gamma(2s)) receptor currents expressed in Xenopus oocytes. Sub-maximal (EC(20)) GABA currents were typically enhanced by co-applications of 3-300 microM (+)-menthol (e.g. by approximately 2-fold at 50 microM) >(More)
Male Sprague-Dawley rats were assigned to one of three dietary groups [standard diet (Cont; n = 8), standard diet plus bovine colostrum powder (BColost 1.7 g/kg; n = 8), or goat milk powder (GMilk 1.7 g/kg; n = 8)] to determine the ability of these supplements to reduce gastrointestinal hyperpermeability induced by heat. Raising core body temperature of(More)
GABA(A) receptors meet all the pharmacological criteria required to be considered important general anaesthetic targets. In the following study, the modulatory effects of various commercially available and novel cyclohexanols were investigated on recombinant human γ-aminobutyric acid (GABA(A), α(1)β(2)γ(2s)) receptors expressed in Xenopus oocytes, and(More)
The effect of tenotomy on Extensor Digitorum Longus (EDL) muscle, brought about by removal of anterior tibialis muscle was studied in the rat. Hypertrophy as well as hyperplasia of the muscle fibres were observed following tenotomy of intact muscle. The transplanted muscle regenerated after tenotomy in the form of a flat strap. The weight, length, breadth(More)
Effect of exercise has been studied on intact and transplanted extensor digitorum longus (EDL) muscle in rats. Majority of muscle fibres hypertrophied and a few showed hyperplasia in intact and transplanted EDL muscle after exercise. The weight, dimensions and diameter of muscle fibres increased, while total muscle area, number of muscle fibres and the(More)
Regeneration of rat plantaris muscle has been studied without predeneration. The original muscle fibres were completely degenerated within one week, but were completely regenerated at the end of experiment. The weight of regenerate showed 51% recovery. The breadth, length and total area of muscle and number of muscle fibres was less by 42, 37, 26 and 29%(More)
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