Nikhil S. Padhye

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CONTEXT Symptoms and quality of life (QOL) are critically important in hematopoietic stem cell transplantation (HSCT). However, few studies have examined these factors by transplant type among diverse cultures. OBJECTIVES To identify and compare QOL and symptom severity and prevalence by transplant type in a diverse population having HSCT. METHODS The(More)
Transition from fetal to neonatal life is likely the most physiologically demanding time of life. Complex changes in major organ system functioning and reorganization of metabolic processes must occur rapidly to achieve postnatal homeostasis. Identifying the neonate with subtle signs of unsuccessful transition is a challenge to the perinatal health care(More)
BACKGROUND Little is known about the effects of hypothermia therapy and subsequent rewarming on the PQRST intervals and heart rate variability (HRV) in term newborns with hypoxic-ischemic encephalopathy (HIE). OBJECTIVES This study describes the changes in the PQRST intervals and HRV during rewarming to normal core body temperature of 2 newborns with HIE(More)
BACKGROUND Maturation of the autonomic nervous system has not been studied in high-risk very low birth weight (VLBW) infants in the first few weeks of life. AIM To characterize developmental changes in autonomic nervous system activity of high-risk VLBW infants from 23 to 38 weeks post-menstrual age by measuring heart rate variability (HRV). STUDY(More)
The objective of this longitudinal study, conducted in a neonatal intensive care unit, was to characterize the response to pain of high-risk very low birth weight infants (<1,500 g) from 23 to 38 weeks post-menstrual age (PMA) by measuring heart rate variability (HRV). Heart period data were recorded before, during, and after a heel lanced or wrist(More)
Diet guidelines recommend increasing dietary diversity. Yet, metrics for dietary diversity have neither been well-defined nor evaluated for impact on metabolic health. Also, whether diversity has effects independent of diet quality is unknown. We characterized and evaluated associations of diet diversity and quality with abdominal obesity and type II(More)
OBJECTIVE To obtain fetal magnetocardiogram (fMCG) recordings in preterm fetuses in both shielded and unshielded clinical settings. METHODS Seventeen fMCG recordings were obtained from 6 low-risk fetuses of 26-35 weeks' postmenstrual age. The superconducting quantum interference device biomagnetometer was positioned over the gravid abdomen, and the(More)
In a pilot randomized controlled trial involving overweight or obese participants with type 2 diabetes, we find that smartphone users have sharply higher adherence to self-monitoring of diet, physical activity, blood glucose, and body weight, as compared to paper diary users. By characterizing the pattern of adherence with the probability of continuation of(More)
The purposes of this pilot study are to describe the 24-hr patterns of dyspnea, fatigue, and peak expiratory flow rate (PEFR) in patients with chronic obstructive pulmonary disease (COPD) and examine their interrelationships. The repeated-measures design protocol involved 10 patients with moderate to severe COPD who self-assessed dyspnea, fatigue, and PEFR(More)
Fetal heart rate variability (fHRV) is useful for noninvasive assessment of the status of the autonomic nervous system of the developing fetus. In this pilot study we acquired fetal magnetocardiograms (fMCG) in a magnetically shielded environment. Each recording was of 5-minute duration and was subsequently repeated in a high-frequency noise environment to(More)