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Stat3 is activated by phosphorylation on Tyr-705, which leads to dimer formation, nuclear translocation, and regulation of gene expression. Serine phosphorylation of Stat3 by mitogen-activated protein kinase has also been observed in cells responding to epidermal growth factor and shown to affect its tyrosine phosphorylation and transcriptional activity.(More)
A low-diameter, fast interconnection network is going to be a prerequisite for building exascale machines. A two-level direct network has been proposed by several groups as a scalable design for future machines. IBM's PERCS topology and the dragonfly network discussed in the DARPA exascale hardware study are examples of this design. The presence of multiple(More)
The advent of petascale computing has introduced new challenges (e.g. heterogeneity, system failure) for programming scalable parallel applications. Increased complexity and dynamism in science and engineering applications of today have further exacerbated the situation. Addressing these challenges requires more emphasis on concepts that were previously of(More)
Despite the identification of many factors that facilitate ribosome assembly, the molecular mechanisms by which they drive ribosome biogenesis are poorly understood. Here, we analyze the late stages of assembly of the 50S subunit using Bacillus subtilis cells depleted of RbgA, a highly conserved GTPase. We found that RbgA-depleted cells accumulate late(More)
Fractures of the distal femur, proximal tibia, and patella that occur adjacent to a total knee replacement may be very difficult to treat. Fixation options are compromised because of the short articular segment, frequent comminution, pre-existing osteoporosis, previous surgical incisions, and the presence of the knee implant itself. This review article(More)
Chromosome territories (CTs) in higher eukaryotes occupy tissue-specific non-random three-dimensional positions in the interphase nucleus. To understand the mechanisms underlying CT organization, we mapped CT position and transcriptional changes in undifferentiated embryonic stem (ES) cells, during early onset of mouse ES cell differentiation and in(More)
We present our implementation of the HPC Challenge Class II (productivity) benchmarks in the Charm++ [1] programming paradigm. Our submission focuses on explaining how over-decomposed, message-driven, migratable objects enhance the clarity of expression of parallel programs and also enable the runtime system to deliver portable performance. Our submission(More)
Physical forces in the form of substrate rigidity or geometrical constraints have been shown to alter gene expression profile and differentiation programs. However, the underlying mechanism of gene regulation by these mechanical cues is largely unknown. In this work, we use micropatterned substrates to alter cellular geometry (shape, aspect ratio, and size)(More)
RbgA is an essential GTPase that participates in the assembly of the large ribosomal subunit in Bacillus subtilis and its homologs are implicated in mitochondrial and eukaryotic large subunit assembly. How RbgA functions in this process is still poorly understood. To gain insight into the function of RbgA we isolated suppressor mutations that partially(More)