Nikesh V Patel

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A genome-wide scan was conducted in two F(2) intercrosses, C57BL/6J (B6)xDBA/2J (D2) and BALB/cJ (C)xLP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD> or =4.3) were detected on chromosomes 9 and 19 for(More)
The haloperidol-induced increase of Fos-like immunoreactive (Fos-li) neurons in the basal ganglia was compared in the C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains. The D2 strain is 10-fold more sensitive than the B6 strain to haloperidol-induced catalepsy, a putative animal model of the extrapyramidal symptoms (EPS) seen after the administration of(More)
A genomewide scan was conducted to detect quantitative trait loci (QTLs) for haloperidol-induced catalepsy in a C57BL/6J (B6) x DBA/2J (D2) F2 intercross (N = 678). Significant QTLs (LOD, > 4.3) were detected on chromosomes 1 and 9. The relative position of the QTL on chromosome 1 is similar to open-field activity QTLs previously identified by Flint et al.(More)
An HPTLC method was developed for Qualitative and Quantitative Estimation of Gallic Acid and Ascorbic Acid in Polyherbal Tablets (Amalant and Sookshma Triphala Tablet) containing Embelica Officinalis, using precoated HPTLC silica gel 60 F254 as Stationary Phase and Mobile Phase for Gallic Acid is Toluene: Ethyl Acetate: Formic Acid (6:3:1v/v/v) and for(More)
Transdermal drug delivery systems of Paroxetine hydrochloride have been formulated by using solvent casting method. Matrix type patches were prepared by using cellulose acetate butyrate(CAB) and ethyl cellulose (EC) polymers by incorporating polyethylene glycol 200, 400,600,DIbutyl phthalate and ethylene glycol as plasticizer, respectively Formulated(More)
Glycerol was first discovered by Karl Wilhelm Scheele. He synthesized and characterized many other chemical compounds such as tartaric acid, citric acid and lactic acid. Glycerol is also known as 1,2,3-propanetriol as it contains three hydroxyl groups there so, it is also termed as polyol compound. It is the principal byproduct obtained during(More)
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