Nika Lalek

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BACKGROUND The effects of pollen immunotherapy on effector cells of allergic inflammation, such as mast cells and basophils, are poorly understood. OBJECTIVE For this reason, we conducted an open study on basophil allergen threshold sensitivity during birch pollen immunotherapy. METHODS Basophil sensitivity was measured by CD63 flow cytometry in 14(More)
BACKGROUND Adverse systemic reactions (SRs) are more common in honeybee venom immunotherapy (VIT) than in wasp VIT. Factors that might be associated with SRs during the honeybee VIT are poorly understood. OBJECTIVE Our aim was to evaluate risk factors for SRs during the build-up phase of honeybee venom immunotherapy. METHODS We included 93 patients who(More)
INTRODUCTION Chronic urticaria (CU) severely affects quality of life. If symptoms are not controlled by antihistamines, patients need immunomodulatory drugs. Recent studies show a tremendous effect of omalizumab, a monoclonal antibody against human IgE in refractory CU. METHODS We report on the use of omalizumab in four patients with CU. By reviewing(More)
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